Results 41 to 50 of about 251,536 (320)

Presymptomatic risk assessment for chronic non-communicable diseases [PDF]

, 2010
The prevalence of common chronic non-communicable diseases (CNCDs) far overshadows the prevalence of both monogenic and infectious diseases combined. All CNCDs, also called complex genetic diseases, have a heritable genetic component that can be used for
AC Morrison, AJ MacGregor, AS Daar, Badri Padhukasahasram, C Kyogoku, C Tysk, CG Loftus, D Bentley, Daryl J. Thomas, DE Reich, Dietrich A. Stephan, E Zeggini, EF Remmers, Elana Silver, Eran Halperin, Heather Trumbower, JC Barrett, Jennifer Wessel, JK Pritchard, JM Chan, JT Salonen, KM Narayan, KM Small, LB Lusted, LJ Scott, MF Doran, Michele Cargill, MS Sandhu, NR Wray, O Kempthorne, Q Lu, Q Yang, R King, S Kathiresan, Thorkild I. A. Sorensen   +34 more
core   +8 more sources

Genetic variability, stability and heritability for quality and yield characteristics in provitamin A cassava varieties [PDF]

, 2020
Open Access Article; Published online: 25 Jan 2020Cassava is widely consumed in many areas of Africa, including Ghana, and is a major part of most household diets.
Biljon, A. van, Kulakow, P., Labuschagne, M., Manu-Aduening, J., Parkes, E., Peprah, B.B.   +5 more
core   +1 more source

Heritable and non-heritable uncommon causes of stroke

Journal of Neurology, 2020
Despite intensive investigations, about 30% of stroke cases remains of undetermined origin. After exclusion of common causes of stroke, there is a number of rare heritable and non-heritable conditions, which often remain misdiagnosed, that should be additionally considered in the diagnosis of cryptogenic stroke.
Bersano, A., Kraemer, M., Burlina, A., Mancuso, M., Finsterer, J., Sacco, S., Salvarani, C., Caputi, L., Chabriat, H., Oberstein, S. Lesnik, Federico, A., Lasserve, E. Tournier, Hunt, D., Dichgans, M., Arnold, M., Debette, Stephanie, Markus, H. S.   +16 more
openaire   +4 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S]

Journal of Lipid Research, 2019
Heritability of LPA allele, apo(a) isoform sizes, and isoform-associated lipoprotein(a) [Lp(a)] levels was studied in 82 Caucasian and African-American families with two parents and two children (age: 6–74 years).
Byambaa Enkhmaa, Erdembileg Anuurad, Wei Zhang, Kyoungmi Kim, Lars Berglund   +4 more
doaj   +1 more source

Accuracy and responses of genomic selection on key traits in apple breeding [PDF]

, 2016
open13siThe application of genomic selection in fruit tree crops is expected to enhance breeding efficiency by increasing prediction accuracy, increasing selection intensity and decreasing generation interval.

core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Heritability Estimated Using 50K SNPs Indicates Missing Heritability Problem in Holstein Breeding [PDF]

Genomics & Informatics, 2015
Previous studies in Holstein have shown 35% to 51.8% heritability in milk production traits, such as milk yield, fat, and protein, using pedigree data.
Donghyun Shin, Kyoung-Do Park, Sojoeng Ka, Heebal Kim, Kwang-hyeon Cho   +4 more
doaj   +1 more source

Relationship Between Physiological Characteristic and Bean Quality on Some Cocoa Clones (Theobroma Cacao L.) [PDF]

, 2015
Photosynthesis is one of the physiological process that influence the bean weight and this process related with the efectiveness of the stomata character and chlorophyll content in the leaves.
Sari, I. A. (Indah), Susilo, A. W. (Agung), Zakariyya, F. (Fakhrusy)   +2 more
core   +3 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source