Results 41 to 50 of about 64,627 (210)

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Knowledge, attitudes, and practices of primary caregivers of gastric cancer patients regarding postoperative dietary management

BMC Cancer
Background Family caregivers of gastric cancer (GC) patients after gastrectomy have a strong demand for nutrition knowledge. This study investigates the knowledge, attitudes, and practices (KAP) of primary caregivers of GC patients regarding ...
Desheng Luo, Hongtao Xu, Chuan Jiang, Jingjing Zheng, Dan Wu, Laizhen Tou, Haifeng Que, Zheng Sun   +7 more
doaj   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

The prognostic role of palliative gastrectomy in advanced gastric cancer: a systematic review and meta-analysis

BMC Cancer
Background The effectiveness of palliative gastrectomy for advanced GC remains a topic of debate. This study sought to establish whether palliative gastrectomy has an impact on prolonging survival.
Desheng Luo, Hongtao Xu, Chuan Jiang, Jingjing Zheng, Dan Wu, Laizhen Tou, Haifeng Que, Zheng Sun   +7 more
doaj   +1 more source

Modified technique of extraperitoneal colostomy without incision of the posterior rectus sheath

Scientific Reports, 2021
Extraperitoneal colostomy is a widely used technique during abdominoperineal resection (APR) operation for lower rectal cancer. This technique has been reported to be effective to prevent the postoperative parastomal hernia in some retrospective studies,
Tao Zhang, Daye Yang, Gongping Sun, Dewei Zhang   +3 more
doaj   +1 more source

Risk of hernia formation after radical prostatectomy [Elektronisk resurs] : a comparison between open and robot-assisted laparoscopic radical prostatectomy within the prospectively controlled LAPPRO trial

, 2022
Purpose: In addition to incisional hernia, inguinal hernia is a recognized complication to radical retropubic prostatectomy. To compare the risk of developing inguinal and incisional hernias after open radical prostatectomy compared to robot-assisted ...
Stranne, J.,, Tyritzis, S. I.,, Wessman, C.,, Hugosson, J.,, Nilsson, H.,, Carlsson, S.,, Bjartell, A.,, Thorsteinsdottir, T.,, Steineck, Gunnar,, Lantz, A.,, Wiklund, P.,, Haglind, E.,, Lund University.   +12 more
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

The management of recurrent hiatal hernia: a single-center retrospective study

BMC Surgery
Purpose Hiatal hernia (HH), characterized by gastric mucosa displacement > 2 cm above the diaphragm, presents significant challenges with recurrence rates ranging from 10 to 60%.
Minxian Zhao, Xiaoli Liu, Haiyun Li, Yusheng Nie, Lei Guan, Ruotong Zheng, Yingmo Shen, Huiqi Yang   +7 more
doaj   +1 more source

A protocol for developing core outcome sets for laparoscopic hiatal hernia repair

Trials, 2022
Background Hiatal hernias negatively damage patients’ health and life quality. Laparoscopic hiatal hernia repair is currently the gold standard for the treatment of hiatal hernia (LHHR).
Xiaoli Liu, Qiuyue Ma, Jie Chen, Huiqi Yang   +3 more
doaj   +1 more source