Results 61 to 70 of about 64,627 (210)

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

HOXC11-mediated regulation of mitochondrial function modulates chemoresistance in colorectal cancer

BMC Cancer
Background Chemoresistance remains a significant challenge in colorectal cancer (CRC) treatment, necessitating a deeper understanding of its underlying mechanisms.
Shicheng Chu, Xiang Ren, Lianmeng Cao, Chong Ma, Kai Wang   +4 more
doaj   +1 more source

Analysis of operation procedure and effect for emergency surgery in general hospital during novel coronavirus pneumonia period

BMC Surgery, 2020
Background Novel coronavirus pneumonia (NCP) outbreak in Wuhan, China in early 2020, resulted in over 80 thousand infections in China. At present, NCP has an explosive growth in the world.
Yuchen Liu, Minggang Wang, Yingmo Shen, Jie Chen   +3 more
doaj   +1 more source

Co-expression of CMTM6 and PD-L1: a novel prognostic indicator of gastric cancer

Cancer Cell International, 2021
Background CKLF Like MARVEL Transmembrane Domain Containing 6 (CMTM6) is involved in the epigenetic regulation of genes and tumorigenesis. Programmed cell death ligand 1 (PD-L1) is closely related to the prognosis of some human cancers.
Chao Zhang, Shutao Zhao, Xudong Wang
doaj   +1 more source

Inguinal hernia is a common complication in lower midline incision surgery

, 2007
Inguinal hernia is a known complication after radical retropubic prostatectomy (RRP). We have investigated whether other types of lower midline incision surgery in males increase the risk of inguinal hernia. Male patients operated with open prostatectomy
Lodding, Pär,, Stranne, Johan,, Hugosson, Jonas,   +2 more
core   +1 more source

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Geriatric nutritional risk index as a predictor of major postoperative complications in emergency femoral hernia patients

BMC Surgery
Background To evaluate the prognostic values of GNRI for major postoperative complications in emergency femoral hernia patients. Methods In this cross-sectional study, we enrolled 105 emergency femoral hernia patients.
Qiuyue Ma, Xiaoli Liu, Chen Liang, Huiqi Yang, Jie Chen, Yingmo Shen   +5 more
doaj   +1 more source

Essential Updates 2024–2026: Advances in Colorectal Cancer Surgery

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Surgical innovation in colorectal cancer is increasingly judged not by technical feasibility alone, but by whether it improves oncological outcomes, preserves function, reduces morbidity, or makes difficult procedures more reproducible. This structured narrative review examines major surgical studies published from January 2024 through July ...
Hiroyasu Kagawa, Yusuke Kinugasa
wiley   +1 more source

Laparoscopic Surgery Is Associated With Reduced Small Bowel Obstruction Risk After Colorectal Cancer Surgery: A Nationwide Cohort Study of 5458 Patients

Annals of Gastroenterological Surgery, EarlyView.
Abbreviated Abstract This nationwide retrospective cohort study of 5458 colorectal cancer surgeries across 32 Japanese institutions examined the effects of laparoscopic surgery, adhesion prevention materials (APMs), and stoma creation on the 5‐year risk of small bowel obstruction (SBO).
Takeshi Yamada, Fumihiko Fujita, Ken Eto, Kozo Kataoka, Norio Yukawa, Kiichi Sugimoto, Rai Shimoyama, Atsuko Fukazawa, Kensuke Kumamoto, Yuichi Takayama, Akira Komono, Akihisa Matsuda, Ryo Ohta, Hiromichi Sonoda, Koichi Okuya, Keisuke Ihara, Yasuyuki Yokoyama, Takuya Nishino, Yasuki Akiyama, Daisuke Ichikawa   +19 more
wiley   +1 more source

Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank

, 2022
Purpose: Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci.
Wei, J., Haggerty, S. P., Resurreccion, W. K., Helfand, B. T., Shi, Z., Na, R., Ujiki, M. B., Zheng, S. L., Xu, J., Attaar, M.   +9 more
core   +1 more source