Results 61 to 70 of about 318,860 (359)

HOXC11-mediated regulation of mitochondrial function modulates chemoresistance in colorectal cancer

BMC Cancer
Background Chemoresistance remains a significant challenge in colorectal cancer (CRC) treatment, necessitating a deeper understanding of its underlying mechanisms.
Shicheng Chu, Xiang Ren, Lianmeng Cao, Chong Ma, Kai Wang   +4 more
doaj   +1 more source

Spigelian Hernia

Annals of Surgery, 1974
Nine cases of Spigelian hernia treated during a period of five years are presented. The literature is reviewed and the importance of recognizing the condition is stressed. The main pathological and clinical features are discussed.
Y, Weiss, O Z, Lernau, S, Nissan
openaire   +3 more sources

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation

Advanced Science, EarlyView.
MSC‐EVs alleviate peritoneal inflammation and fibrogenesis by disrupting the H3K18la‐CCL2 axis and crosstalk between mesothelial cells and Ly6c2⁺ macrophages. Model cartoons are constructed using the Biorender website (https://www.biorender.com/), and a usage license is obtained. Abstract Peritoneal dialysis (PD), as a renal replacement therapy, relies
Qiang Huang, Yuxiang Sun, Pengpeng Kuang, Juan Sun, Dandan Guo, Long Peng, Hu Zhou, Qinrong Song, Zhihao Huo, Canming Li, Janusz Witowski, Zhaoyong Hu, Hui Peng   +12 more
wiley   +1 more source

Robotic-assisted versus laparoscopic incisional hernia repair: differences in direct costs from a Brazilian public institute perspective [PDF]

, 2022
Thiago Nogueira Costa, Francisco Tustumi, Lucas Sousa Maia Ferros, Bárbara Buccelli Colonno, Ricardo Zugaib Abdalla, Ulysses Ribeiro, Ivan Cecconello   +6 more
openalex   +1 more source

Chest CT scoring for evaluation of lung sequelae in congenital diaphragmatic hernia survivors

, 2020
Objectives Data on long-term structural lung abnormalities in survivors of congenital diaphragmatic hernia (CDH) is scarce. The purpose of this study was to develop a chest computed tomography (CT) score to assess the structural lung sequelae in CDH ...
Aukland, Stein M., Beel, Emma, Boon, Mieke, Debeer, Anne, Proesmans, Marijke, Vermeulen, François   +5 more
core   +1 more source

PACS‐2 Mitigates NPSC Apoptosis and Intervertebral Disc Degeneration by Preserving MAM Integrity via the SP1/LRRK2/Mfn2 Axis

Advanced Science, EarlyView.
This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang, Jiaqi Wang, Chenhao Zhao, Qiuwei Li, Zhigang Zhang, Huaqing Zhang, Chongyu Jia, Luping Zhou, Yanxin Wang, Yu Chen, Kaixuan Li, Xu Yan, Jie Fang, Haibao Wang, Dandan Wang, Pingping Su, Jingyu Zhang, Zhiwei Chen, Renjie Zhang, Cailiang Shen   +19 more
wiley   +1 more source

Surgical methods and outcomes of inguinal hernia repair in children, adolescents and young adults in a retrospective cohort study

Scientific Reports
Laparoscopic repair as an alternative option for pediatric inguinal hernia has increased worldwide. We aimed to analyze the surgical methods of inguinal hernia repair among children, adolescents and young adults, and evaluate the surgical outcomes of ...
Qiuyue Ma, Xiaoli Liu, Zhenyu Zou, Chen Liang, Jie Chen, Huiqi Yang, Yingmo Shen   +6 more
doaj   +1 more source

Addition of Capecitabine to Adjuvant Chemotherapy May be the Most Effective Strategy for Patients With Early-Stage Triple-Negative Breast Cancer: A Network Meta-Analysis of 9 Randomized Controlled Trials

Frontiers in Endocrinology, 2022
Background and ObjectivePrevious studies determined the therapeutic effects of capecitabine-based chemotherapy regimens on early-stage triple-negative breast cancer (TNBC).
Zhiyang Li, Jiehua Zheng, Zeqi Ji, Lingzhi Chen, Jinyao Wu, Juan Zou, Yiyuan Liu, Weixun Lin, Jiehui Cai, Yaokun Chen, Yexi Chen, Hai Lu   +11 more
doaj   +1 more source

Exact Solution for a 1-dimensional model for Reptation [PDF]

, 2006
We discuss the exact solution for the properties of the recently introduced ``necklace'' model for reptation. The solution gives the drift velocity, diffusion constant and renewal time for asymptotically long chains.
Drzewinski, Andrzej, van Leeuwen, J. M. J.   +1 more
core   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source