Results 61 to 70 of about 300,155 (312)

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

open access: yesAdvanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang   +13 more
wiley   +1 more source

BRD9 inhibition promotes PUMA-dependent apoptosis and augments the effect of imatinib in gastrointestinal stromal tumors

open access: yesCell Death and Disease, 2021
Gastrointestinal stromal tumors (GISTs) are primarily characterized by activating mutations of tyrosine kinase or platelet-derived growth factor receptor alpha.
Jianfeng Mu   +4 more
doaj   +1 more source

MHD simulations of the eruption of coronal flux ropes under coronal streamers [PDF]

open access: yes, 2017
Using three-dimensional magnetohydrodynamic (MHD) simulations, we investigate the eruption of coronal flux ropes underlying coronal streamers and the development of a prominence eruption. We initialize a quasi-steady solution of a coronal helmet streamer, into which we impose at the lower boundary the slow emergence of a part of a twisted magnetic ...
arxiv   +1 more source

Intestinal perforation after surgical treatment for incisional hernia. iatrogenic or idiopathic? [PDF]

open access: yes, 2018
Intestinal perforation (IP) is a life-threatening gastroenterological condition requiring urgent surgical care, which may present itself as an uncommon complication following incisional hernia repair surgery, most often because of iatrogenic traumatism ...
Amorosi, V   +5 more
core   +1 more source

Smart Organic–Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma

open access: yesAdvanced Science, EarlyView.
The tumor microenvironment‐responsive nanoagonists are developed using an organic–inorganic copolymer composed of the polymer (PC6AB) and manganous phosphate ionic oligomers (MnP). PC6AB with membranolytic activity selectively interacts with tumor cell membranes to induce immunogenic cell death, while MnP activates the STING pathway in immune cells ...
Shiming Zhang   +14 more
wiley   +1 more source

HOXC11-mediated regulation of mitochondrial function modulates chemoresistance in colorectal cancer

open access: yesBMC Cancer
Background Chemoresistance remains a significant challenge in colorectal cancer (CRC) treatment, necessitating a deeper understanding of its underlying mechanisms.
Shicheng Chu   +4 more
doaj   +1 more source

Systematic Review and Guidelines for Management of Scrotal Inguinal Hernias

open access: yesJournal of Abdominal Wall Surgery, 2023
Introduction: Of the more than 20 million patients undergoing groin hernia repair annually worldwide, 6% are scrotal hernias in high resource countries rising to 67% in low resource countries which represents a heavy disease burden on relatively young ...
Hanh Minh Tran   +3 more
doaj   +1 more source

Comorbidities Associated with Large Abdominal Aortic Aneurysms [PDF]

open access: yes, 2019
BACKGROUND: Abdominal aortic aneurysm has become increasingly important owing to demographic changes. Some other diseases, for example, cholecystolithiasis, chronic obstructive pulmonary disease, and hernias, seem to co-occur with abdominal aortic ...
Althoff, Christian E.   +6 more
core   +1 more source

Short‐term outcomes of intracorporeal anastomosis in laparoscopic colectomy for colon cancer: A nationwide, multi‐institutional cohort study in Japan (ICAN study)

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
We retrospectively compared intracorporeal and extracorporeal anastomosis in patients undergoing laparoscopic colectomy for colon cancer in 46 institutions by using propensity‐score matching. Intracorporeal anastomosis showed advantages over extracorporeal anastomosis in terms of blood loss, intraoperative vascular injury, bowel recovery, and length of
Tomohiro Yamaguchi   +92 more
wiley   +1 more source

Perioperative outcomes of esophagectomy after doublet versus docetaxel‐based triplet neoadjuvant chemotherapy in older patients: A nationwide inpatient database study in Japan

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
In this nationwide inpatient database study of 5229 patients aged 70–79 years who underwent esophagectomy for cancer after neoadjuvant chemotherapy, overlap propensity score weighting analysis showed that neoadjuvant docetaxel‐based triplet regimen (docetaxel, cisplatin, and 5‐fluorouracil) was not associated with a higher incidence of perioperative ...
Yuki Hirano   +11 more
wiley   +1 more source

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