Results 91 to 100 of about 23,835 (226)

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Zoster vaccination is associated with a reduction of zoster in elderly patients with chronic kidney disease. [PDF]

, 2016
BACKGROUND: Growing epidemiological evidence demonstrates increased zoster risks in people with chronic kidney disease (CKD). Study objectives were to determine zoster vaccine effectiveness in individuals with CKD in pragmatic use.
Langan, Sinéad M, Margolis, David J, Nitsch, Dorothea, Smeeth, Liam, Thomas, Sara L   +4 more
core   +1 more source

Can we refute a role for infections in Alzheimer's disease pathogenesis?

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract While a growing body of literature suggests a role for infections in Alzheimer's disease (AD), microbial contributions to AD remains a contentious topic, in part due to challenges in reconciling the positive evidence with studies reporting null findings.
Zena K. Chatila, Michael R. Duggan, Esther Silberberg, Juan Fernandez, Lavinia A. Auber, Elizabeth M. Bradshaw, Nikki M. Schultek   +6 more
wiley   +1 more source

Herpes Zoster and Post-Herpetic Neuralgia—Diagnosis, Treatment, and Vaccination Strategies

Pathogens
Introduction: Herpes zoster is caused by the reactivation of latent varicella infection within the sensory ganglia, caused by the varicella-zoster virus (VZV).
Delwyn Zhi Jie Lim, Hong Liang Tey, Brenda Mae Alferez Salada, Jolene Ee Ling Oon, Ee-Jin Darren Seah, Nisha Suyien Chandran, Jiun Yit Pan   +6 more
doaj   +1 more source

Tofacitinib in the management of active psoriatic arthritis: patient selection and perspectives. [PDF]

, 2019
Tofacitinib is an oral Janus kinase inhibitor approved for the treatment of psoriatic arthritis (PsA). It provides an alternative option for patients who have had an inadequate response and tolerance to other disease modifying antirheumatic drugs (DMARDs)
Beck, Kristen M, Liao, Wilson, Ly, Karen, Orbai, Ana-Maria, Smith, Mary P   +4 more
core  

Sequential Varicella and Herpes Zoster in an Immunocompetent Adult

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Varicella and herpes zoster, caused by primary infection and reactivation of varicella‐zoster virus (VZV) respectively, can present with a wide spectrum of cutaneous and systemic complications. This case highlights an uncommon sequential presentation of varicella and zoster in an immunocompetent adult in noncontiguous dermatomes and emphasizes
Bibek Sharma, Supriya Paudel
wiley   +1 more source

Examining the potential for porcine-derived islet cells to harbour viral pathogens [PDF]

, 2018
With an onus on safety in the potential use of porcine islet cells as a treatment for diabetes, the use of animals lacking exogenous pathogens is clearly important and multilevel screening strategies have been presented on testing animals and the product.
Crossan, Claire, Gianello, Pierre, Mourad, Nizar, O'Hara, Zoe, Scobie, Linda   +4 more
core   +2 more sources

Herpes zoster (HZ) vaccine coverage and confidence in Italy: a Nationwide cross-sectional study, the OBVIOUS project

BMC Infectious Diseases
Background Herpes Zoster is an age dependent disease and as such it represents a problem in the Italian social context, where the demographic curve is characterized by an overrepresentation of the elderly population.
Aurelia Salussolia, Angelo Capodici, Francesca Scognamiglio, Giusy La Fauci, Giorgia Soldà, Marco Montalti, Zeno Di Valerio, Maria Pia Fantini, Anna Odone, Claudio Costantino, Heidi J. Larson, Julie Leask, Jacopo Lenzi, Davide Gori, on behalf of the OBVIOUS board   +14 more
doaj   +1 more source

A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene [PDF]

, 2018
Varicella-zoster virus (VZV), an alphaherpesvirus, establishes lifelong latent infection in the neurons of >90% humans worldwide, reactivating in one-third to cause shingles, debilitating pain and stroke. How VZV maintains latency remains unclear.
Braspenning, S.E. (Shirley E.), Breuer, J. (Judith), Cohrs, R.J. (Randall ), Depledge, D.P. (Daniel P.), Mori, Y. (Yasuko), Ouwendijk, W.J.D. (Werner), Sadaoka, T. (Tomohiko), Verjans, G.M.G.M. (George)   +7 more
core   +6 more sources