Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity. [PDF]
PLoS PathogensHerpes simplex virus 1 (HSV-1) UL12 encodes a highly conserved 5' → 3' alkaline exonuclease that is essential for the production of infectious virus.
Nidhi Sharma +10 more
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Antibody reveals conformational latch regulating dimerization in β- and γ-herpesvirus proteases [PDF]
Nature CommunicationsHuman herpesvirus (HHV) replication depends on the HHV protease (HHV Pr), an enzyme essential for capsid maturation. Because HHV Pr must transition from an inactive monomer to an active dimer, disrupting dimerization is a promising antiviral strategy. We
Marcell A. Zimanyi +7 more
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Callitrichine gammaherpesvirus 3 and Human alphaherpesvirus 1 in New World Primate negative for yellow fever virus in Rio de Janeiro, Brazil [PDF]
Memorias do Instituto Oswaldo Cruz, 2022 BACKGROUND Herpesvirus transmission between humans and non-human primate (NHP) can occur through contact scratches with lesions, infected saliva, and mainly through contaminated food.
Flávia Freitas de Oliveira Bonfim +9 more
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Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System
Viruses, 2022 Herpesviruses have complex mechanisms enabling infection of the human CNS and evasion of the immune system, allowing for indefinite latency in the host. Herpesvirus infections can cause severe complications of the central nervous system (CNS).
Saima Ahmed +8 more
doaj +1 more source
Vaccines, 2021 Theoretically, the subunit herpes zoster vaccine ShingrixTM could be used as a varicella vaccine that avoids the risk of developing shingles from vaccination, but bedside mixing strategies and the limited supply of the adjuvant component QS21 have made ...
Han Cao +3 more
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Binding of Transmembrane Mucins to Galectin-3 Limits Herpesvirus 1 Infection of Human Corneal Keratinocytes [PDF]
Journal of Virology, 2013 ABSTRACT Epithelial cells lining mucosal surfaces impose multiple barriers to viral infection. At the ocular surface, the carbohydrate-binding protein galectin-3 maintains barrier function by cross-linking transmembrane mucins on the apical glycocalyx. Despite these defense mechanisms, many viruses have evolved to exploit fundamental cellular
A M, Woodward, J, Mauris, P, Argüeso
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Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda [PDF]
AIDS, 2018 Kaposi sarcoma is a HIV-associated malignancy caused by human herpesvirus-8 (HHV-8) that occurs at highest incidence in sub-Saharan Africa. Kaposi sarcoma patients often present with inflammatory symptoms associated with higher mortality.We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 supplementation ...
Anna E, Coghill +5 more
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Ranid Herpesvirus 3 Infection in Common Frog Rana temporaria Tadpoles
Emerging Infectious Diseases, 2023 Ranid herpesvirus 3 (RaHV3) is a recently discovered virus associated with skin disease in frogs. We detected RaHV3 DNA in free-ranging common frog (Rana temporaria) tadpoles, consistent with premetamorphic infection.
Francesco C. Origgi, Annette Taugbøl
doaj +1 more source
Porcine Lymphotropic Herpesviruses (PLHVs) and Xenotranplantation
Viruses, 2021 Porcine lymphotropic herpesviruses -1, -2 and -3 (PLHV-1, PLHV-2 and PLHV-3) are gammaherpesviruses which are widespread in pigs. They are closely related to the Epstein–Barr virus (EBV) and Kaposi sarcoma herpesvirus, both of which cause severe diseases
Joachim Denner
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Herpes Group Viruses: a Seroprevalence Study in Hemodialysis Patients
Acta Clinica Croatica, 2017 Herpes group viruses (herpes simplex virus, HSV; varicella-zoster virus, VZV; cytomegalovirus, CMV; and Epstein-Barr virus, EBV) remain an important cause of morbidity in immunocompromised persons.
Tatjana Vilibić-Čavlek +4 more
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