Binding of Transmembrane Mucins to Galectin-3 Limits Herpesvirus 1 Infection of Human Corneal Keratinocytes [PDF]
Journal of Virology, 2013 ABSTRACT Epithelial cells lining mucosal surfaces impose multiple barriers to viral infection. At the ocular surface, the carbohydrate-binding protein galectin-3 maintains barrier function by cross-linking transmembrane mucins on the apical glycocalyx. Despite these defense mechanisms, many viruses have evolved to exploit fundamental cellular
A M, Woodward, J, Mauris, P, Argüeso
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Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda [PDF]
AIDS, 2018 Kaposi sarcoma is a HIV-associated malignancy caused by human herpesvirus-8 (HHV-8) that occurs at highest incidence in sub-Saharan Africa. Kaposi sarcoma patients often present with inflammatory symptoms associated with higher mortality.We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 supplementation ...
Anna E, Coghill +5 more
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Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Envelope Glycoprotein gB Induces the Integrin-Dependent Focal Adhesion Kinase-Src-Phosphatidylinositol 3-Kinase-Rho GTPase Signal Pathways and Cytoskeletal Rearrangements [PDF]
Journal of Virology, 2004 ABSTRACT Human herpesvirus 8 (HHV-8; Kaposi's sarcoma-associated herpesvirus) envelope glycoprotein gB possesses an RGD motif, interacts with α3β1 integrin, and uses it as one of the entry receptors. HHV-8 induces the integrin-dependent focal adhesion kinase (FAK), a critical step in the outside-in signaling pathways necessary for the ...
Neelam, Sharma-Walia +4 more
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Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase [PDF]
Journal of Virology, 2018 ABSTRACT Human herpesvirus 8 (HHV-8) encodes four viral interferon regulatory factors (vIRF-1 to -4) that likely function to suppress innate immune and cellular stress responses through inhibitory interactions with various cellular proteins involved in these activities.
Qiwang Xiang +6 more
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Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A [PDF]
, 2019 Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Boyd, Joseph R. +12 more
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Varicella zoster virus-associated Chorioretinitis: a case report
BMC Ophthalmology, 2018 Background Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained during the course of resolution ...
Joo Yeon Kim +3 more
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A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion [PDF]
, 2017 The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many
Beatrice Plougastel-Douglas +11 more
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An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]
, 2020 beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip +8 more
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Hutchinson’s sign of ophthalmic zoster
Clinical Case Reports, 2020 A 77‐year‐old woman presented with ophthalmic zoster and nasal tip involvement, consistent with Hutchinson's sign. Ocular examination disclosed a swollen upper eyelid, chemosis, conjunctival injection, pus, and mild corneal endothelial decompensation ...
Johanna Frary +2 more
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Frontiers in Endocrinology, 2022 Infection of immunosuppressed transplant patients with the human γ-herpesvirus Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD), an often fatal complication.
Maša Mavri +13 more
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