Results 61 to 70 of about 12,706 (193)

Activation and inhibition of sirtuins: From bench to bedside

Medicinal Research Reviews, Volume 45, Issue 2, Page 484-560, March 2025.
Abstract The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging.
Francesco Fiorentino, Emanuele Fabbrizi, Antonello Mai, Dante Rotili   +3 more
wiley   +1 more source

Unveiling the causal link between herpes virus infection and cutaneous leukocytoclastic angiitis: Insights from Mendelian randomization analysis

Rheumatology &Autoimmunity, Volume 5, Issue 1, Page 50-57, March 2025.
This Mendelian randomization (MR) analysis aimed to assess the causal relationship between the Herpes virus (HSV, herpes simplex virus; HHV‐6, human herpesvirus 6; VZV, varicella‐zoster virus; CMV cytomegalovirus; EBV, Epstein‐Barr virus) and leukocytoclastic angiitis.
Heyi Zhang, Jinglei Xie, Yifei Wang, Ruolan Li, Ying Mao, Luyao Song, Zhenyang Yuan, Qinyi Su, Yuehong Huo, Xiaofeng Li, Shengxiao Zhang   +10 more
wiley   +1 more source

Antiviral Activity of Carbon Dots: Strategies and Mechanisms of Action

Small Structures, Volume 6, Issue 3, March 2025.
Carbon dots are capable to interact with viruses through different mechanisms of action, having an antiviral and virucidal effect: inhibition of viral entry into the cells, disruption of viral replication, and damage of the virion structure. The COVID‐19 pandemic profoundly changes the perception of the impact of viral diseases on society and the ...
Plinio Innocenzi, Davide De Forni, Franco Lori   +2 more
wiley   +1 more source

Prevalence of HSV‐1/HSV‐2 and CMV Infections in Infertile Men and Their Impact on Sperm Parameters: A Cross‐Sectional Study in Iran

Health Science Reports, Volume 8, Issue 2, February 2025.
ABSTRACT Background and Aims Viral infections are significant contributors to infertility. This study aimed to determine the prevalence of Herpes Simplex Virus 1 and 2 (HSV‐1/HSV‐2) and cytomegalovirus (CMV) infections in men with infertility, compared to a control group of fertile men.
Seyed Mansour Salar, Fahime Edalat, Arash Letafati, Seyed Mehdi Kalantar, Fatemeh Javanmardi, Ahmad najafi, Mahmoud vakili, Afagh Moattari   +7 more
wiley   +1 more source

Identification and Functional Analysis of PANoptosis‐Associated Genes in the Progression From Sepsis to ARDS

Immunity, Inflammation and Disease, Volume 13, Issue 1, January 2025.
This study identifies four key PANoptosis‐related genes (NDRG1, DDX3X, PTPRC, and TNFSF8) that are differentially expressed in sepsis and septic ARDS. The prediction model incorporating these genes shows high diagnostic accuracy, with NDRG1 emerging as a potential therapeutic target due to its significant expression and correlation with immune cells ...
Zhong‐Hua Lu, Yan Tang, Hu Chen, Feng Liu, Mei Liu, Lu Fu, Xian‐Kai Wang, Ming‐Juan Li, Wei‐Li Yu, Yun Sun   +9 more
wiley   +1 more source

Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence.

PLoS Pathogens, 2016
CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (MCMV ...
Mathew Clement, Morgan Marsden, Maria A Stacey, Juneid Abdul-Karim, Silvia Gimeno Brias, Diana Costa Bento, Martin J Scurr, Peter Ghazal, Casey T Weaver, Gianluca Carlesso, Simon Clare, Simon A Jones, Andrew Godkin, Gareth W Jones, Ian R Humphreys   +14 more
doaj   +1 more source

The prevalence of human cytomegalovirus DNA in gliomas of Brazilian patients

Memorias do Instituto Oswaldo Cruz, 2012
Members of the Herpesviridae family have been implicated in a number of tumours in humans. At least 75% of the human population has had contact with cytomegalovirus (HCMV).
Renata Fragelli Fonseca, Marcia Tie Kawamura, José Antônio Oliveira, Anselmo Teixeira, Gilda Alves, Maria da Glória da Costa Carvalho   +5 more
doaj   +1 more source

Modulation of Lymphotoxin β Surface Expression by Kaposi's Sarcoma‐Associated Herpesvirus K3 Through Glycosylation Interference

Journal of Medical Virology, Volume 97, Issue 1, January 2025.
ABSTRACT Kaposi's sarcoma‐associated herpesvirus (KSHV) employs diverse mechanisms to subvert host immune responses, contributing to its infection and pathogenicity. As an immune evasion strategy, KSHV encodes the Membrane‐Associated RING‐CH (MARCH)‐family E3 ligases, K3, and K5, which target and remove several immune regulators from the cell surface ...
Soowon Kang, Kevin Brulois, Youn Jung Choi, Shaoyan Zhang, Jae U. Jung   +4 more
wiley   +1 more source

Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO

Annals of Intensive Care, 2019
Background Herpesviridae reactivation among non-immunocompromised critically ill patients is associated with impaired prognosis, especially during acute respiratory distress syndrome (ARDS).
Sami Hraiech, Eline Bonnardel, Christophe Guervilly, Cyprien Fabre, Anderson Loundou, Jean-Marie Forel, Mélanie Adda, Gabriel Parzy, Guilhem Cavaille, Benjamin Coiffard, Antoine Roch, Laurent Papazian   +11 more
doaj   +1 more source

Herpes viruses and human papilloma virus in nasal polyposis and controls

Brazilian Journal of Otorhinolaryngology, 2015
INTRODUCTION: Chronic rhinosinusitis with nasal polyps is a multifactorial disease entity with an unclear pathogenesis. Contradictory data exist in the literature on the potential implication of viral elements in adult patients with chronic ...
Dimitrios Ioannidis, Vasileios A. Lachanas, Zoe Florou, John G. Bizakis, Efthymia Petinaki, Charalampos E. Skoulakis   +5 more
doaj   +1 more source