Results 31 to 40 of about 1,129 (145)

A point mutation in a herpesvirus polymerase determines neuropathogenicity. [PDF]

PLoS Pathogens, 2007
Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the
Laura B Goodman, Arianna Loregian, Gillian A Perkins, Josie Nugent, Elizabeth L Buckles, Beatrice Mercorelli, Julia H Kydd, Giorgio Palù, Ken C Smith, Nikolaus Osterrieder, Nicholas Davis-Poynter   +10 more
doaj   +1 more source

Molecular Surveillance of EHV-1 Strains Circulating in France during and after the Major 2009 Outbreak in Normandy Involving Respiratory Infection, Neurological Disorder, and Abortion

Viruses, 2019
Equine herpesvirus 1 (EHV-1) is an Alphaherpesvirus infecting not only horses but also other equid and non-equid mammals. It can cause respiratory distress, stillbirth and neonatal death, abortion, and neurological disease. The different forms of disease
Gabrielle Sutton, Marie Garvey, Ann Cullinane, Marion Jourdan, Christine Fortier, Peggy Moreau, Marc Foursin, Annick Gryspeerdt, Virginie Maisonnier, Christel Marcillaud-Pitel, Loïc Legrand, Romain Paillot, Stéphane Pronost   +12 more
doaj   +1 more source

Equid Herpesvirus-1 Exploits the Extracellular Matrix of Mononuclear Cells to Ensure Transport to Target Cells

iScience, 2020
Summary: Mononuclear cells are the first line of defense against microbial infection. Yet, several viruses have evolved different mechanisms to overcome host defenses to ensure their spread.
Mohamed Kamel, Selvaraj Pavulraj, Beatrix Fauler, Thorsten Mielke, Walid Azab   +4 more
doaj   +1 more source

Autophagy in cultured murine neurons infected with equid herpesvirus 1

Acta virologica, 2014
In this study we investigated the relationship of equid herpesvirus 1 (EHV-1) infection to autophagy in primary culture of murine neurons. Infection with both Jan-E and Rac-H strains of EHV-1 resulted in the formation of autophagosomes in the cytoplasm during early stages of infection, while in late stages of infection autophagosomes were mainly ...
J, Cymerys, D, Miszczak, A, Słońska, A, Golke, M W, Bańbura   +4 more
openaire   +3 more sources

Genomic and phylogenetic analysis of Argentinian Equid Herpesvirus 1 strains

Virus Genes, 2008
Equid Herpesvirus 1 (EHV-1) has long been causally implicated in the occurrence of abortion, neonatal death, respiratory disease, and neurological disorders in horses. This study analyzed for the first time the characteristics of the genomic section of Argentinian EHV-1 strains and reconstructed the phylogeny in order to establish their origin.
Martín Ocampos, Giselle Paula, Fuentealba, Nadia Analía, Sguazza, Guillermo Hernán, Jones, Leandro Roberto, Cigliano, María Marta, Barbeito, Claudio Gustavo, Galosi, Cecilia Mónica   +6 more
openaire   +4 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Acute neurologic presentation of a 2‐year‐old standardbred colt with multicentric diffuse large B cell lymphoma

Equine Veterinary Education, EarlyView.
Summary Lymphoma in horses is uncommon and rarely diagnosed as a cause of ataxia. This case report describes a 2‐year‐old Standardbred cryptorchid colt who presented with acute onset of grade 3–4/5 spinal ataxia in all four limbs, with the hindlimbs more severely affected than forelimbs and severe proprioceptive deficits.
K. MacMillan, J. Burns, E. John, M. Buote   +3 more
wiley   +1 more source

Silent pressure: Unveiling spinal lymphoma in horses and its parallels to other species

Equine Veterinary Education, EarlyView.
Summary Though the nervous system is an uncommon location for lymphoma, the disease should remain a differential diagnosis in some cases of ataxia in equids. Diagnosis of lymphoma can be challenging, although a combination of cytology, histopathology and immunophenotyping can aid in definitive diagnosis and therefore more accurately guide treatment and
H. E. Taylor, D. Luethy
wiley   +1 more source

Immunohistochemical approach to the pathogenesis of clinical cases of Bovine Herpesvirus type 5 infections

Diagnostic Pathology, 2010
Meningoencephalitis by Herpesvirus type 5 (BoHV-5) in cattle has some features that are similar to those of herpetic encephalitis in humans and other animal species. Human Herpesvirus 3 (commonly known as Varicella-zoster virus 1), herpes simplex viruses
Cardoso Tereza C, Ferrari Heitor F, Garcia Andrea F, Bregano Livia C, Andrade Alexandre L, Nogueira Adriana HC   +5 more
doaj   +1 more source

Air embolism secondary to suspected lymphatic tissue disruption with severe exercise‐induced pulmonary haemorrhage

Equine Veterinary Education, EarlyView.
Summary Air embolism is rare in horses and typically associated with complications following intravenous catheterisation or other medical procedures. Exercise‐induced pulmonary haemorrhage (EIPH) is common in racehorses but not usually associated with air embolism. This report describes a case of air embolism in a 4‐year‐old Thoroughbred with EIPH. The
J. Wittenberg, K. Drozdzewska, K. Landmann, A. Voß, K. Kunze, D. Rutenberg, A. D. Gruber, H. Gehlen   +7 more
wiley   +1 more source