Results 131 to 140 of about 635,179 (242)

Construction of Reverse Genetics System for Feline Calicivirus FCV‐BJ616 and Proteomic Analysis

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
This study successfully isolated the FCV‐BJ616 strain derived from cats and established a reverse genetics system. In vivo experiments showed that rFCV‐BJ616 exhibits wild‐type virulence, leading to high fever, weight loss, and multi‐organ lesions in infected cats. Proteomic analysis indicated that both rFCV‐BJ616 and FCV‐BJ616 share similar regulatory
Chunmei Xu, Jingjie Zhao, Hao Liu, Haotian Gu, Xinming Tang, Lin Liang, Jiabo Ding, Shaohua Hou, Xiaomin Zhao, Ruiying Liang   +9 more
wiley   +1 more source

Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.

PLoS Pathogens
Apoptosis is a critical host antiviral defense mechanism. But many viruses have evolved multiple strategies to manipulate apoptosis and escape host antiviral immune responses.
Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang, Changjiang Weng   +7 more
doaj   +1 more source

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Brentuximab Vedotin With Adriamycin, Vinblastine, and Dacarbazine for Patients Aged 18–59 Years With Untreated Advanced Stage Classical Hodgkin Lymphoma: The Largest Real‐Life Series From Southern Italy Cancer Centers

European Journal of Haematology, Volume 116, Issue 2, Page 174-184, February 2026.
ABSTRACT BV + AVD is increasingly used for frontline treatment of stage III/IV cHL. Young adults and adults (Ya&A) were the most common patients treated with BV + AVD in clinical trials but have not been studied in non‐trial settings. We conducted a real‐life study in secondary and tertiary cancer centers to evaluate the PFS in 18–59 years aged ...
Marco Picardi, Annamaria Vincenzi, Claudia Giordano, Novella Pugliese, Alessia Scarpa, Assunta Lombardi, Elena Vigliar, Giancarlo Troncone, Rosaria Cappiello, Massimo Mascolo, Giovanni Esposito, Maria Prastaro, Ciro Santoro, Roberta Esposito, Carlo Gabriele Tocchetti, Ciro Mainolfi, Rosa Fonti, Silvana Del Vecchio, Fabio Trastulli, Mario Annunziata, Rossella Iula, Catello Califano, Marianna Carchia, Marcello Persico, Alessia Salemme, Emanuele Nicolai, Andrea Soricelli, Marco Salvatore, Fabrizio Pane   +28 more
wiley   +1 more source

EBV+ and Kaposi's Sarcoma Herpesvirus-Associated Multicentric Castleman Disease in a Patient With HIV Infection: A Case Report. [PDF]

Case Rep Infect Dis
Multicentric Castleman disease is a rare proliferative disease of lymphoid tissue. It has rarely been reported in Asian countries, particularly in HIV‐positive patients. Here, we report a case of Kaposi’s sarcoma herpesvirus‐associated Multicentric Castleman disease (KSHV‐MCD).
Huang MY, Li Z, Zhang W, Chen HY, Liu J, Li CX.   +5 more
europepmc   +2 more sources

Host immune response to cytomegalovirus [PDF]

, 1987
To confirm that immediate-early (IE) genes of murine cytomegalovirus (MCMV) give rise to antigens recognized by specific cytolytic T lymphocytes (CTL), a 10.8-kilobase fragment of MCMV DNA which is abundantly transcribed at IE times was transfected into ...
Keil, Günther M., Koszinowski, Ulrich H., Reddehase, Matthias J., Schickedanz, Jörg   +3 more
core  

Impact of BoLA‐DRB3 Polymorphisms on Clonality of Bovine Leukaemia Virus‐Infected Cells of Cattle With Lymphoma

HLA, Volume 107, Issue 2, February 2026.
ABSTRACT Bovine leukaemia virus (BLV) infects cattle, integrates into the host genome as a provirus, and induces a persistent infection that remains asymptomatic but can cause leukaemia/lymphoma. Most BLV‐infected cell clones are created by massive depletion, and a few of these infected cell clones expand through the mitotic cycle, leading to the onset
Noriko Fukushi, Meripet Polat Yamanaka, Ryosuke Matsuura, Sonoko Watanuki, Susumu Saito, Yasunobu Matsumoto, Keisuke Fukumoto, Kazuyoshi Hosomichi, Jinliang Wang, Shin‐nosuke Takeshima, Yoko Aida   +10 more
wiley   +1 more source

European Code Against Cancer, 5th edition – cancer‐causing infections and related interventions

Molecular Oncology, Volume 20, Issue 1, Page 96-116, January 2026.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations related to cancer‐causing infections, namely H. pylori, HPV, HBV, HCV and HIV, positioned as recommendation number 12.
Catharina Johanna Alberts, Paul Bloem, Silvia de Sanjosé, Sophie Grabar, Marcis Leja, Peter Malfertheiner, Mojca Matičič, Francis Mégraud, Francesco Negro, Martyn Plummer, Maarten Schim van der Loeff, Graciela Balbín, Josefina Salazar, Hajo Zeeb, Ariadna Feliu, Erica D'Souza, David Ritchie, Carolina Espina, Silvia Franceschi   +18 more
wiley   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

Advanced Science, Volume 13, Issue 4, 19 January 2026.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou, Hongchao Zhu, Xiaonan Sun, Ni Zhang, Song Wang, Xuexing Zheng, Xiaoyun Wang, Yueyue Feng, Fuzhen Zhang, Xingyu Li, Rui Li, Xiaomeng Wang, Yuanyuan Han, Jun Wang, Chuanhong Wang, Xiaoyang Yao, Hongmei Wang, Hongbin He   +17 more
wiley   +1 more source