Results 91 to 100 of about 636,801 (264)
HERPESVIRUS INFECTIONS IN CHILDREN WITH RECURRENT RESPIRATORY DISEASES
Детские инфекции (Москва), 2018 The article presents the role of herpesviral infections caused by the herpes simplex virus (HSV), the Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpesvirus type 6 (HHV-6) in 36 children with recurrent respiratory tract diseases at the age
M. Yu. Lysenkova +8 more
doaj +1 more source
Optimal Behavior Prior: Data-Efficient Human Models for Improved Human-AI Collaboration [PDF]
arXiv, 2022 AI agents designed to collaborate with people benefit from models that enable them to anticipate human behavior. However, realistic models tend to require vast amounts of human data, which is often hard to collect. A good prior or initialization could make for more data-efficient training, but what makes for a good prior on human behavior?
arxiv
Inhibition of a viral enzyme by a small-molecule dimer disruptor. [PDF]
, 2009 We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi's sarcoma-associated herpesvirus (KSHV) by screening an alpha-helical mimetic library.
Arnold, Leggy A +7 more
core
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, EarlyView.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
The Robust Kernel Association Test [PDF]
arXiv, 2019 Testing the association between SNP effects and a response is a common task. Such tests are often carried out through kernel machine methods based on least squares, such as the Sequence Kernel Association Test (SKAT). However, these least squares procedures assume a normally distributed response, which is often violated. Other robust procedures such as
arxiv
Structure of the herpes-simplex virus portal-vertex [PDF]
, 2018 Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein–Barr virus and Kaposi sarcoma–associated herpesvirus.
Bhella, David +3 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri +10 more
wiley +1 more source
Viral miRNAs Alter Host Cell miRNA Profiles and Modulate Innate Immune Responses
Frontiers in Immunology, 2018 Prevalence of the members of herpesvirus family in oral inflammatory diseases is increasingly acknowledged suggesting their likely role as an etiological factor. However, the underlying mechanisms remain obscure.
Afsar R. Naqvi +5 more
doaj +1 more source
A beta-herpesvirus with fluorescent capsids to study transport in living cells. [PDF]
, 2012 Fluorescent tagging of viral particles by genetic means enables the study of virus dynamics in living cells. However, the study of beta-herpesvirus entry and morphogenesis by this method is currently limited.
Bauerfeind, Rudolf +11 more
core +4 more sources
SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation
Aging Cell, EarlyView.p62 exhibits diminished expression in aging skin and senescent cells. p62 serves to inhibit the accumulation of USP7 during senescence induction. The Tyr‐67 residue within the PB1 domain or Gln‐418 within the UBA domain of p62 forms a hydrogen bond with Ala‐993 of the Ubl5 domain of USP7.
Liu Chen +10 more
wiley +1 more source