Results 71 to 80 of about 1,291,105 (289)

Statistical properties of thermodynamically predicted RNA secondary structures in viral genomes

, 2008
By performing a comprehensive study on 1832 segments of 1212 complete genomes of viruses, we show that in viral genomes the hairpin structures of thermodynamically predicted RNA secondary structures are more abundant than expected under a simple random ...
A. Tuplin, C. Thurner, D.S.H. Chew, F. Lillo, F. Lillo, F. Lillo, F. Ratcliff, G.P. Schroth, H.O. Smith, J.S. Mattick, M. Spanò, M. Spanò, M.Y. Leung, P. Rice, P. Simmonds, P.E. Warburton, R. Cox, R. N. Mantegna, R.C. Lee, S. Miccichè, S.R. Eddy   +20 more
core   +1 more source

Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil.

Arquivos de Neuro-Psiquiatria, 2011
Viral meningitis is a common infectious disease of the central nervous system (CNS) that occurs worldwide. The aim of this study was to identify the etiologic agent of lymphomonocytary meningitis in Curitiba, PR, Brazil. During the period of July 2005 to
L. R. Vidal, S. M. Almeida, I. Messias-Reason, M. B. Nogueira, M. Debur, L. Pessa, L. Pereira, Indianara Rotta, G. A. Takahashi, C. S. Silveira, Josianne Maria Reimann Araújo, S. M. Raboni   +11 more
semanticscholar   +1 more source

Evolutionary History of Endogenous Human Herpesvirus 6 Reflects Human Migration out of Africa

Molecular biology and evolution, 2020
Human herpesvirus 6A and 6B (HHV-6) can integrate into the germline, and as a result, ∼70 million people harbor the genome of one of these viruses in every cell of their body. Until now, it has been largely unknown if 1) these integrations are ancient, 2)
A. Aswad, Giulia Aimola, D. Wight, Pavitra Roychoudhury, Cosima Zimmermann, Joshua A. Hill, D. Lassner, H. Xie, Meei-Li W Huang, N. Parrish, H. Schultheiss, C. Venturini, S. Lager, Gordon C. S. Smith, D. S. Charnock-Jones, J. Breuer, A. Greninger, B. Kaufer   +17 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Seropositivity of selected chronic infections and different measures of obesity.

PLoS ONE, 2020
The impact of sex-specific body fat distribution on the susceptibility to five chronic infections, helicobacter pylori and human herpesviruses 3 to 6 (i.e.
Dennis Freuer, Jakob Linseisen, Tim Waterboer, Frank Pessler, Carlos Alberto Guzmán, Nina Wawro, Annette Peters, Christa Meisinger   +7 more
doaj   +1 more source

Pathogen or Bystander: Clinical Significance of Detecting Human Herpesvirus 6 in Pediatric Cerebrospinal Fluid

Journal of Clinical Microbiology, 2020
Human herpesvirus 6 (HHV-6) is an important cause of meningitis and meningoencephalitis. As testing for HHV-6 in cerebrospinal fluid (CSF) is more readily available using the FilmArray Meningitis/Encephalitis panel (FA-ME; BioFire Diagnostics, Salt Lake ...
U. Pandey, A. Greninger, Greg R. Levin, K. Jerome, Vikram Anand, J. Dien Bard   +5 more
semanticscholar   +1 more source

Kaposi's Sarcoma-Associated Herpesvirus Forms a Multimolecular Complex of Integrins (αVβ5, αVβ3, and α3β1) and CD98-xCT during Infection of Human Dermal Microvascular Endothelial Cells, and CD98-xCT Is Essential for the Postentry Stage of Infection [PDF]

Journal of Virology, 2008
ABSTRACTKaposi's sarcoma-associated herpesvirus (KSHV) interacts with cell surface heparan sulfate (HS) and α3β1 integrin during the early stages of infection of human dermal microvascular endothelial cells (HMVEC-d) and human foreskin fibroblasts (HFF), and these interactions are followed by virus entry overlapping with the induction of preexisting ...
Fu Zhang Wang, Hari Raghu, Laszlo Varga, Sathish Sadagopan, Bala Chandran, Mohanan Valiya Veettil, Neelam Sharma-Walia   +6 more
openaire   +2 more sources

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Advanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou   +14 more
wiley   +1 more source

Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.

PLoS Pathogens
Apoptosis is a critical host antiviral defense mechanism. But many viruses have evolved multiple strategies to manipulate apoptosis and escape host antiviral immune responses.
Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang, Changjiang Weng   +7 more
doaj   +1 more source

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source