Results 251 to 260 of about 629,421 (295)

4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as Non-Nucleoside Inhibitors of Human Cytomegalovirus and Related Herpesvirus Polymerases

Journal of Medicinal Chemistry, 2005
A novel series of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potential antivirals against human herpesvirus infections resulting from human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and varicella-zoster virus (VZV).
Mark E, Schnute, Michele M, Cudahy, Roger J, Brideau, Fred L, Homa, Todd A, Hopkins, Mary L, Knechtel, Nancee L, Oien, Thomas W, Pitts, Roger A, Poorman, Michael W, Wathen, Janet L, Wieber   +10 more
openaire   +2 more sources

Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties

Archives of Virology, 2011
Human herpesvirus 8 (HHV-8) triggers proangiogenic behaviour in endothelial cells by inducing monocyte chemoattractant protein 1 (MCP-1) through activation of Nuclear Factor κB (NF-κB). However, NF-κB inhibition still results in partial MCP-1 induction and consequent angiogenesis, suggesting the involvement of another transcriptional pathway.
CASELLI, Elisabetta, BENEDETTI, Sabrina, GRIGOLATO, Jessica, Caruso A., DI LUCA, Dario   +4 more
openaire   +3 more sources

Detection and Analysis of Protein‐Protein Interactions between KU70 and BHRF1, a BCL2 viral analog within Human gamma herpesvirus 4

The FASEB Journal, 2020
The Epstein‐Barr virus, also known as human gamma herpesvirus 4 (HHV‐4), affects more than 90% of the adult human population worldwide. To prevent premature death of the host cell, HHV‐4 encodes for BHRF1, an anti‐apoptotic protein with sequence and structural similarities to other proteins involved in apoptosis such as BCL2, BAX and BAK, among others.
Sheighlah McManus, Alexander Emami, Alberto Zamora   +2 more
openaire   +1 more source

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

Bioorganic & Medicinal Chemistry Letters, 2007
A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Mark E, Schnute, David J, Anderson, Roger J, Brideau, Fred L, Ciske, Sarah A, Collier, Michele M, Cudahy, MariJean, Eggen, Michael J, Genin, Todd A, Hopkins, Thomas M, Judge, Euibong J, Kim, Mary L, Knechtel, Sajiv K, Nair, James A, Nieman, Nancee L, Oien, Allen, Scott, Steven P, Tanis, Valerie A, Vaillancourt, Michael W, Wathen, Janet L, Wieber   +19 more
openaire   +2 more sources

Identification of a novel septin 4 protein binding to human herpesvirus 8 kaposin A protein using a phage display cDNA library

Journal of Virological Methods, 2007
Human herpesvirus 8 (HHV-8) is associated with the development of Kaposi's sarcoma and several other human malignancies. Kaposin A protein of HHV-8 has been demonstrated as inducing tumorigenic transformation, being responsible for nuclear receptor coactivators in the transforming activity.
Cheng-Wen, Lin, Ping-Feng, Tu, Nai-Wan, Hsiao, Ching-Yao, Chang, Lei, Wan, Yu-Tsun, Lin, Hsueh-Wei, Chang   +6 more
openaire   +2 more sources

Effect of IL‐12 and soluble IL‐4 receptor on the herpesvirus infection in human SCID chimeras whose Th2 cells predominate

Immunology & Cell Biology, 2004
Th2 cytokines, commonly detected in burn patients, have been shown as inhibitors for the generation of Th1 cells that are essential for the host's resistance against herpes simplex virus type 1 (HSV‐1) infection. In this study, the possibility of immunological treatment through the regulation of Th1/Th2 responses was examined in two kinds of human ...
Tatsushi, Katakura, Makiko, Kobayashi, David N, Herndon, Fujio, Suzuki   +3 more
openaire   +2 more sources

Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7

Journal of Virology
ABSTRACT Human herpesvirus 8 (HHV-8), associated with Kaposi sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman disease, encodes four interferon regulatory factor homologs, vIRFs 1–4, that interact with and inhibit various mediators of host-cell defense against virus infection.
Zunlin Yang, John Nicholas
openaire   +2 more sources

Tim-1 and Tim-4 mediate entry of the human Kaposi’s sarcoma-associated herpesvirus and the related rhesus monkey rhadinovirus

2023
ABSTRACTKaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different receptors, among them heparan sulfate proteoglycans, Eph family receptors, and integrins.
Stefano Scribano, Sarah Schlagowski, Shanchuan Liu, Thomas Fricke, Xiaoliang Yang, Frank Neipel, Anna K. Großkopf, Bojan F. Hörnich, Marija Backovic, Armin Ensser, Alexander S. Hahn   +10 more
openaire   +1 more source

DIAGNOSIS OF AN ALLERGIC REACTION TO ANTIBIOTICS IN AN PATIENT WITH ACTIVE HUMAN HERPESVIRUS -4, -6 TYPE INFECTION (CLINICAL CASE).

Georgian medical news, 2022
Beta-lactam antibiotics (BLAs) can provoke drug hypersensitivity reactions, particularly delayed-type reactions. This article presents a case of drug allergy with manifestations of Stevens-Johnson syndrome (SJD) in a 42-year-old man with yersiniosis and active herpesvirus -4, -6 type, who received amoxacillin with clavulanic acid. The patient underwent
S, Zubchenko, A, Havrylyuk, M, Lomikovska, I, Kril, S, Chuiko   +4 more
openaire   +1 more source

Cervical cancer prevention and control in women living with human immunodeficiency virus

Ca-A Cancer Journal for Clinicians, 2021
Philip E Castle, Vikrant V Sahasrabuddhe
exaly