Results 51 to 60 of about 617,702 (270)

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Perturbation of lytic and latent gammaherpesvirus infection in the absence of the inhibitory receptor CEACAM1. [PDF]

, 2009
Control of gammaherpesvirus infections requires a complex, well orchestrated immune response regulated by positive and negative co-signaling molecules.
Kammerer Robert, Zimmermann, Wolfgang, Adler, Heiko, Guggemoos Simone, El-Gogo, Susanne, El-Gogo, S., Nicole Beauchemin, Beauchemin, Nicole, Heiko Adler, Beauchemin, N., Robert Kammerer, Kammerer, Robert, Kammerer, R., Beauchemin Nicole, Wolfgang Zimmermann, Susanne El-Gogo, Guggemoos, S., Guggemoos, Simone, Adler Heiko, Zimmermann Wolfgang, Zimmermann, W., Adler, H., El-Gogo Susanne, Simone Guggemoos   +23 more
core   +1 more source

Long Non-Coding RNAs: Novel Players in Regulation of Immune Response Upon Herpesvirus Infection

Frontiers in Immunology, 2018
Herpesviruses have developed a variety of sophisticated immune evasion strategies to establish lifelong latent infection, including the use of long non-coding RNAs (lncRNAs).
Waqas Ahmed, Waqas Ahmed, Zheng-Fei Liu, Zheng-Fei Liu   +3 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

A beta-herpesvirus with fluorescent capsids to study transport in living cells. [PDF]

, 2012
Fluorescent tagging of viral particles by genetic means enables the study of virus dynamics in living cells. However, the study of beta-herpesvirus entry and morphogenesis by this method is currently limited.
Lisa Marcinowski, Marcinowski, Lisa, Ulrich H Koszinowski, Christophe Jung (152124), Jens von Einem, Gaul, Ulrike, Paul Walther, Einem, Jens von, Jens B Bosse, Paul Walther (113867), Ruzsics, Zsolt, Ulrike Gaul, Ulrich H. Koszinowski (152143), Bosse, Jens B., Zsolt Ruzsics (75383), Leonhard Popilka (152101), Leonhard Popilka, Christophe Jung, Jens B. Bosse (138966), Lisa Marcinowski (138962), Jens B. Bosse, Martina Taeglich (152115), Rudolf Bauerfeind (152093), Taeglich, Martina, Koszinowski, Ulrich H., Hannah Striebinger, Zsolt Ruzsics, Ulrike Gaul (3154), Ulrich H. Koszinowski, Jung, Christophe, Hannah Striebinger (152128), Martina Taeglich, Jens von Einem (152134), Bauerfeind, Rudolf, Striebinger, Hannah, Rudolf Bauerfeind, Walther, Paul, Popilka, Leonhard   +37 more
core   +1 more source

New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems

Viruses, 2017
Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness.
Matthew R. Pennington, Eric C. Ledbetter, Gerlinde R. Van de Walle   +2 more
doaj   +1 more source

Pathogenesis of pigeon herpesvirus infection [PDF]

Journal of Comparative Pathology, 1981
Abstract Experiments were designed to investigate the pathogenesis of pigeon herpesvirus (Pigeon herpesvirus 1, PHV) infection. Experimental pharyngeal infection of susceptible pigeons may be followed by viral localization and development of lesions outside the upper digestive and respiratory tracts.
Vindevogel, Henri, Pastoret, Paul-Pierre
openaire   +2 more sources

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Identification and localization of the structural proteins of anguillid herpesvirus 1 [PDF]

, 2011
peer ...
Leroy, B, Vervoort Jacques JM, Dep Infectieziekten Immunologie, Vanderplasschen, A.F., Ruddy Wattiez, Alain F Vanderplasschen, Boeren, S., Vervoort, J, Engelsma, M, van Beurden, S.J., Van Beurden, Steven, Haenen, O, Leroy Baptiste, Leroy, B., Wattiez, R, van Beurden Steven J, Engelsma Marc Y, Boeren, S, Vanderplasschen Alain F, Beurden, S.J., van, Olga LM Haenen, Peeters, B, Rottier, P, Boeren Sjef, Vervoort, J.M., Vanderplasschen, Alain, Baptiste Leroy, Marc Y Engelsma, Haenen Olga LM, Leroy, B.P., Rottier Peter JM, Rottier, P.J.M., Wattiez, R., Peeters Ben PH, Peter JM Rottier, Peeters, B.P.H., Sjef Boeren, Strategic Infection Biology, Haenen, O.L.M., Engelsma, M.Y., Vanderplasschen, A., Jacques JM Vervoort, Steven J van Beurden, Ben PH Peeters, Wattiez Ruddy, Vervoort, J.J.M.   +45 more
core   +1 more source

Post-exposure vaccination improves gammaherpesvirus neutralization.

PLoS ONE, 2007
Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether vaccinating carriers might improve virus neutralization ...
Laurent Gillet, Janet S May, Philip G Stevenson   +2 more
doaj   +1 more source