Results 51 to 60 of about 643,962 (269)

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

The role of mixed Mycoplasma and Herpesvirus infections in case of skin lesions in children

Детские инфекции (Москва), 2019
Numerous literature data show the role of mycoplasma infection in the development of non-respiratory lesions of various organs and systems, including the skin.
H. O. Kuvardina, F. S. Kharlamova, I. V. Polesko, O. V. Shamsheva, O. S. Ostapuschenko   +4 more
doaj   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Modern data on the biology of Human Herpesvirus 6 and pathogenesis of Human Herpesvirus 6-associated clinical conditions (review of scientific publications)

Журнал инфектологии
Despite almost universal detection of human herpesvirus 6 in general population (up to 90% of individuals are considered seropositive), human herpesvirus 6-associated diseases remain poorly explored.
P. A. Drozdovskaya, V. A. Zinserling
doaj   +1 more source

Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy [PDF]

, 2017
KSHV and EBV are gammaherpesviruses strictly linked to human cancers. Even if the majority of cancer cells harbor a latent infection, the few cells that undergo viral replication may contribute to the pathogenesis and maintenance of the virus-associated ...
Cirone, Mara, Faggioni, Alberto, Gilardini Montani, Maria Saveria, Gonnella, Roberta, Granato, Marisa, Romeo, Maria Anele, Santarelli, Roberta, Tiano, Mariangela Sara   +7 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Long Non-Coding RNAs: Novel Players in Regulation of Immune Response Upon Herpesvirus Infection

Frontiers in Immunology, 2018
Herpesviruses have developed a variety of sophisticated immune evasion strategies to establish lifelong latent infection, including the use of long non-coding RNAs (lncRNAs).
Waqas Ahmed, Waqas Ahmed, Zheng-Fei Liu, Zheng-Fei Liu   +3 more
doaj   +1 more source

Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus [PDF]

, 1987
The murine immediate-early (IE) protein pp89 is a nonstructural virus- encoded phosphoprotein residing in the nucleus of infected cells, where it acts as transcriptional activator.
Bertholet, Christine, Jonjic, Stipan, Koszinowski, Ulrich H., Volkmer, Hansjürgen, Wittek, Riccardo   +4 more
core   +4 more sources

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems

Viruses, 2017
Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness.
Matthew R. Pennington, Eric C. Ledbetter, Gerlinde R. Van de Walle   +2 more
doaj   +1 more source