Results 71 to 80 of about 9,254 (260)

Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells [PDF]

, 2000
PURPOSE: Herpetic stromal keratitis (HSK) is a T-cell-mediated inflammatory disease initiated by a herpes simplex virus (HSV) infection of the cornea. Recently, studies in the HSK mouse model have shown that the immunopathogenic T cells
Mooy, C.M. (Cornelia), Osterhaus, A.D.M.E. (Albert), Remeijer, L. (Lies), Verjans, G.M.G.M. (George)   +3 more
core   +1 more source

Nerve growth factor therapy in stage 2 and 3 neurotrophic keratopathy: A prospective, open‐label clinical trial

Eye &ENT Research, Volume 2, Issue 4, Page 275-283, December 2025.
Abstract Background Neurotrophic keratopathy (NK) is a rare degenerative corneal disease characterized by reduced corneal sensitivity and impaired epithelial healing, frequently resulting in persistent epithelial defects and corneal ulcers. Conventional therapies provide symptomatic relief but do not restore corneal innervation, highlighting a ...
Yifei Niu, Qian Wang, Fei Yu, Xuan Zhao, Liu Liu, Po‐Han Fang, Kai Zhou, Tingting Zhang, Saiqun Li, Jin Yuan   +9 more
wiley   +1 more source

Optical coherence tomography angiography in herpetic leucoma

BMC Medical Imaging, 2022
Background Herpes simplex virus (HSV) keratitis remains a leading infectious cause of blindness worldwide. Although all forms of HSV keratitis are commonly recurrent, the risk is greatest in stromal keratitis, which is the most likely to result in ...
Inês Almeida, Libânia Dias, Jeniffer Jesus, Inês Fonseca, Maria João Matias, João Carlos Pedro   +5 more
doaj   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Acyclovir-resistant herpetic keratitis in a solid-organ transplant recipient on systemic immunosuppression

Clinical Ophthalmology, 2013
Liam Daniel Turner,1 Peter Beckingsale1,2,31Princess Alexandra Hospital; 2Terrace Eye Centre; 3Laser Sight, Brisbane, Queensland, AustraliaPurpose: To report a case of acyclovir-resistant herpetic keratitis in a solid-organ lung transplant recipient that
Turner LD, Beckingsale P
doaj  

A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. [PDF]

PLoS ONE, 2014
Both viral and host genetics affect the outcome of herpes simplex virus type 1 (HSV-1) infection in humans and experimental models. Little is known about specific host gene variants and molecular networks that influence herpetic disease progression ...
Richard L Thompson, Robert W Williams, Malak Kotb, Nancy M Sawtell   +3 more
doaj   +1 more source

Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 12, Page 2056-2068, December 2025.
This cohort study of 1793 atopic dermatitis patients (aged ≥ 12) found higher infection rates with Janus kinase inhibitor treatment compared to biologic treatment, particularly for herpes infections, with a history of viral or fungal skin infection as a risk factor associated with infection.
Lian F. van der Gang, Keneshka Atash, Nicolaas P. A. Zuithoff, Inge Haeck, Celeste M. Boesjes, Octavian I. Bacoş‐Cosma, Laura Loman, Marijke Kamsteeg, Simone Stadhouders‐Keet, Albert J. Oosting, Anneke M. T. van Lynden‐van Nes, Klaziena Politiek, Antoni Gostynksi, Lisette Berntsen‐Zandbergen, Wianda A. Christoffers, Annebeth Flinterman, Wouter R. H. Touwslager, Berit Velstra, Shiarra M. Stewart, Francine C. van Erp, Marlies de Graaf, Marie‐Louise A. Schuttelaar, Marjolein S. de Bruin‐Weller   +22 more
wiley   +1 more source

Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation. [PDF]

, 2019
PurposeTo report two cases of neurotrophic keratitis (NK) after micropulse transscleral cyclophotocoagulation (MP-TCP).ObservationsTwo patients with predisposing factors for decreased corneal sensation developed NK 1 month after MP-TCP. Both patients did
Han, Ying, Hsia, Yen C, Ou, Yvonne, Perez, Claudio I, Rose-Nussbaumer, Jennifer   +4 more
core   +1 more source

Clinical and corneal microbial profile of infectious keratitis in a high HIV prevalence setting in rural South Africa [PDF]

, 2016
The purpose of this investigation was to determine the clinical and corneal microbial profile of infectious keratitis in a high human immunodeficiency virus (HIV) prevalence setting in rural South Africa. Data in this cross-sectional study were collected
Baarsma, G.S. (Seerp), Getu, S. (Sarah), Khosa, N.S., McIntyre, J.A. (James), Meenken, C. (Christina), Osterhaus, A.D.M.E. (Albert), Peters, R.P.H. (Remco), Schaftenaar, W. (Willem), Verjans, G.M.G.M. (George)   +8 more
core   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, Volume 21, Issue 29, July 24, 2025.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source