Versatile roles of disordered transcription factor effector domains in transcriptional regulation
The FEBS Journal, EarlyView.Disordered effector domains (EDs) of transcription factors (TFs) play versatile roles in transcriptional regulation. These include mediating protein–protein interactions with protein complexes like, facilitating condensate formation to enhance transcriptional efficiency, modulating DNA‐binding specificity through genome scanning, and serving as hubs ...
Rhea R. Datta +3 more
wiley +1 more source
Loss of Heterochromatin Protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death [PDF]
, 2002 Ilaria Filesi +5 more
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The Potential Use of the Epigenetic Remodeler LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) as a Tool for Crop Improvement [PDF]
, 2023 Natanael Mansilla +3 more
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The FEBS Journal, EarlyView.Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura +8 more
wiley +1 more source
Journal of Fish Diseases, EarlyView.ABSTRACT A 10‐month‐old intact male blue Siamese fighting fish (Betta splendens) was presented to the Purdue University Small Animal Hospital with multiple bilateral masses on the caudal flank. Comprehensive evaluation using impression cytology, histopathology and transmission electron microscopy (TEM) revealed a tumour composed of a mixed‐cell ...
Zi An Yu +2 more
wiley +1 more source
Novel Drosophila Heterochromatin Protein 1 (HP1)/Origin Recognition Complex-associated Protein (HOAP) Repeat Motif in HP1/HOAP Interactions and Chromocenter Associations [PDF]
, 2003 RamaKrishna Badugu +2 more
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Hybridization and gene expression: Beyond differentially expressed genes
Molecular Ecology, EarlyView.Abstract Gene expression has a key role in reproductive isolation, and studies of hybrid gene expression have identified mechanisms causing hybrid sterility. Here, we review the evidence for altered gene expression following hybridization and outline the mechanisms shown to contribute to altered gene expression in hybrids. Transgressive gene expression,
Anna Runemark +2 more
wiley +1 more source
The histone subcode: poly(ADP‐ribose) polymerase‐1 (Parp‐1) and Parp‐2 control cell differentiation by regulating the transcriptional intermediary factor TIF1β and the heterochromatin protein HPlα [PDF]
, 2008 Delphine Quénet +6 more
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Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque
Molecular Ecology, EarlyView.ABSTRACT Genetic variation that impacts gene regulation, rather than protein function, can have strong effects on trait variation both within and between species. Epigenetic mechanisms, such as DNA methylation, are often an important intermediate link between genotype and phenotype, yet genetic effects on DNA methylation remain understudied in natural ...
Christina E. Costa +12 more
wiley +1 more source
The Heterochromatin Protein 1 positively regulates euchromatic gene expression by RNA binding [PDF]
, 2008 Lucia Piacentini +5 more
openalex +1 more source