Results 141 to 150 of about 1,693,917 (277)

H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing

Epigenetics & Chromatin, 2011
Background Endogenous retroviruses (ERVs) are parasitic sequences whose derepression is associated with cancer and genomic instability. Many ERV families are silenced in mouse embryonic stem cells (mESCs) via SETDB1-deposited trimethylated lysine 9 of ...
Maksakova Irina A, Goyal Preeti, Bullwinkel Jörn, Brown Jeremy P, Bilenky Misha, Mager Dixie L, Singh Prim B, Lorincz Matthew C   +7 more
doaj   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Repo-Man/PP1 regulates heterochromatin formation in interphase

Nature Communications, 2017
Repo-Man is a chromosome-binding subunit of protein phosphatase 1 to regulate mitosis. Here, de Castro and colleagues show that Repo-Man also regulates heterochromatin during interphase, and regulates gene repression and chromatin organization.
Inês J. de Castro, James Budzak, Maria L. Di Giacinto, Lorena Ligammari, Ezgi Gokhan, Christos Spanos, Daniela Moralli, Christine Richardson, Jose I. de las Heras, Silvia Salatino, Eric C. Schirmer, Katharine S. Ullman, Wendy A. Bickmore, Catherine Green, Juri Rappsilber, Sarah Lamble, Martin W. Goldberg, Veronica Vinciotti, Paola Vagnarelli   +18 more
doaj   +1 more source

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Frontiers in Immunology, 2012
NETosis, the process wherein neutrophils release highly decondensed chromatin called neutrophil extracellular traps (NETs), has gained much attention as an alternative means of killing bacteria.
Marc eLeshner, Shu eWang, Carrie eLewis, Han eZheng, Xiangyun Amy Chen, Lorraine eSanty, Yanming eWang   +6 more
doaj   +1 more source

Heterochromatin protein 1 regulates longevity and the mitochondrial unfolded protein response

, 2021
Prohibitins (PHB-1 and PHB-2) form a large macromolecular structure at the mitochondrial inner membrane. PHB deficiency shortens the lifespan of wild type animals, but dramatically extends that of metabolically compromised animals, such as insulin/IGF-1 receptor (daf-2) mutants.
Cruz, Patricia de la, Askjaer, Peter, Artal-Sanz, Marta   +2 more
openaire   +4 more sources

Molecular mechanisms of sex determination in Lepidoptera: current status and perspectives

Insect Science, EarlyView.
The genetic basis of sex determination in Lepidoptera was discovered in 2014 in the silkworm Bombyx mori. In this model species, the W chromosome‐derived small piRNA called Fem piRNA downregulates the expression of a Z‐linked gene, Masculinizer (Masc), which leads to the default female‐specific splicing of the doublesex gene (dsxF) and thus to female ...
František Marec, Atsuo Yoshido, Arjen E. van′t Hof   +2 more
wiley   +1 more source

Chromatin Regulation by HP1γ Contributes to Survival of 5-Azacytidine-Resistant Cells

Frontiers in Pharmacology, 2018
Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic ...
Satoshi Imanishi, Tomohiro Umezu, Chiaki Kobayashi, Tomohiko Ohta, Kazuma Ohyashiki, Junko H. Ohyashiki   +5 more
doaj   +1 more source

Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells

Journal of Cell Biology, 2013
The planarian chromatin regulator HP1, at least in part acting through increased expression of Mcm5, inhibits differentiation of adult stem cells and triggers their proliferation in response to injury.
An Zeng, Yong-Qin Li, Chen Wang, Xiao-Shuai Han, Ge Li, Jian-yong Wang, Dang-Sheng Li, Yong Qin, Yufang Shi, G. Brewer, Qing Jing   +10 more
semanticscholar   +1 more source

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, EarlyView.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source