Results 141 to 150 of about 603,291 (199)

Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation

Nature Communications
Functional crosstalk between DNA methylation, histone H3 lysine-9 trimethylation (H3K9me3) and heterochromatin protein 1 (HP1) is essential for proper heterochromatin assembly and genome stability.
Zengyu Shao, Jiuwei Lu, Nelli Khudaverdyan, Jikui Song   +3 more
doaj   +1 more source

Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast

Aging Cell, Volume 24, Issue 4, April 2025.
Extender of chronological lifespan 1 (Ecl1), which inhibits the target of rapamycin complex 1 (TORC1), physically interacts with TORC1 subunits and is necessary for appropriate cellular responses to various stressors, such as starvation, in fission yeast. Several functions of Ecl1 are suppressed by Thr7 phosphorylation when nutrients are abundant.
Hokuto Ohtsuka, Sawa Kawai, Yurika Ito, Yuka Kato, Takafumi Shimasaki, Kazuki Imada, Yoko Otsubo, Akira Yamashita, Emi Mishiro‐Sato, Keiko Kuwata, Hirofumi Aiba   +10 more
wiley   +1 more source

Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors

, 2009
Christian Flueck, Richárd Bártfai, Jennifer Volz, Igor Niederwieser, Adriana M. Salcedo‐Amaya, Blaise Alako, Florian Ehlgen, Stuart A. Ralph, Alan F. Cowman, Zbynek Bozdech, Hendrik G. Stunnenberg, Till S. Voss   +11 more
openalex   +2 more sources

Large‐Scale Clustered Transcriptional Silencing Associated With Cellular Senescence

Aging Cell, Volume 24, Issue 4, April 2025.
Senescence inducing stimuli leads to large‐cluster hypercondensed DNA globules. This architectural phenomenon is associated with geographically clustered transcriptional repression. Such large‐scale clustered silencing of chromosomal segments may drive deep senescence through two possible ways: (1) one or more critical combination of genes, for example
Aditi U. Gurkar, Satoshi Okawa, Christelle Guillermier, Kritika Chaddha, Matthew L. Steinhauser   +4 more
wiley   +1 more source

Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum. [PDF]

Sci Rep, 2019
Bui HTN, Niederwieser I, Bird MJ, Dai W, Brancucci NMB, Moes S, Jenoe P, Lucet IS, Doerig C, Voss TS.   +9 more
europepmc   +1 more source

Evaluation of Different Cryoprotectant Combinations in Vitrification and Slow Freezing for Ovarian Tissue Preservation in Domestic Cats

Reproduction in Domestic Animals, Volume 60, Issue 4, April 2025.
ABSTRACT Over the past decade, increased hunting and habitat disturbance have significantly impacted the endangered population within the Felidae family. Recognising this, it becomes imperative to implement strategies aimed at mitigating this concerning conservation scenario.
Rayane Brandão Ribeiro, Aline Queiroz Rodrigues, Beatriz Alves de Aguiar, Jessyca Karoline Oliveira Silva, Marcus Vinicius Rocha de a Carvalho da Costa, Julliene Larissa dos Santos Bezerra, Yasmin Barboza Ferreira, Ingrid Gracielle Martins da Silva, Tathyana Benetis Piau, Carolina Madeira Lucci, Sônia Nair Báo, Jair Trapé Goulart, Paula Maria Quaglio Bellozi, Fernanda Paulini   +13 more
wiley   +1 more source

DNA hypermethylation preceded by H3K27 trimethylation is linked to downregulation of gene expression in disuse muscle atrophy in male mice

Physiological Reports, Volume 13, Issue 7, April 2025.
Abstract Disuse muscle atrophy can result in downregulated gene expression vital to muscle integrity, yet the mechanisms driving this downregulation remain unclear. Epigenetic alterations regulate transcriptional potential, with repressive changes suppressing gene expression.
Junya Shimizu, Fuminori Kawano
wiley   +1 more source

Recurrent Amplification of the Heterochromatin Protein 1 (HP1) Gene Family across Diptera. [PDF]

Mol Biol Evol, 2018
Helleu Q, Levine MT.
europepmc   +1 more source

Distinct Cytoplasmic and Nuclear Fractions of Drosophila Heterochromatin Protein 1: Their Phosphorylation Levels and Associations with Origin Recognition Complex Proteins [PDF]

, 1998
Da Wei Huang, Laura Fanti, Daniel T.S. Pak, Michael R. Botchan, Sergio Pimpinelli, Rebecca Kellum   +5 more
openalex   +1 more source

Knockdown of heterochromatin protein 1 binding protein 3 recapitulates phenotypic, cellular, and molecular features of aging. [PDF]

Aging Cell, 2019
Neuner SM, Ding S, Kaczorowski CC.
europepmc   +1 more source