Results 141 to 150 of about 87,019 (296)

Molecular mechanisms of sex determination in Lepidoptera: current status and perspectives

Insect Science, EarlyView.
The genetic basis of sex determination in Lepidoptera was discovered in 2014 in the silkworm Bombyx mori. In this model species, the W chromosome‐derived small piRNA called Fem piRNA downregulates the expression of a Z‐linked gene, Masculinizer (Masc), which leads to the default female‐specific splicing of the doublesex gene (dsxF) and thus to female ...
František Marec, Atsuo Yoshido, Arjen E. van′t Hof   +2 more
wiley   +1 more source

Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging

Aging Cell, EarlyView.
A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi, Na Yang, Evelyn Pizano, Lin Wang, James R. Occean, Chang‐Yi Cui, Ling Liu, Christopher Dunn, Frimpong Boadu, Qiong Meng, Nirad Banskota, Jen‐Hao Yang, Jinshui Fan, Supriyo De, Jianlin Cheng, Thomas A. Rando, Vittorio Sartorelli, Payel Sen   +17 more
wiley   +1 more source

Cell adhesion molecule L1 interacts with the chromo shadow domain of heterochromatin protein 1 isoforms α, β, and ɣ via its intracellular domain [PDF]

, 2021
Ralf Kleene, Gabriele Loers, Gastón Castillo, Melitta Schachner, Ralf Kleene, Gabriele Loers, Gastón Castillo, Melitta Schachner, Ralf Kleene, Gabriele Loers, Gastón Castillo, Melitta Schachner   +11 more
openalex   +1 more source

Oocyte Age‐Dependent DNA Damage Can Be Reverted by the DNA Repair Competent Karyoplasm of Young Oocytes

Aging Cell, EarlyView.
As females age, oocyte chromosomal aberrations and DNA damage increase in frequency; this condition is believed to be irreversible. By exposing the aged oocyte nuclei to nuclear factors from young oocytes, the negative effects can be effectively suppressed, restoring their developmental competence. ABSTRACT Mammalian fully grown oocytes are believed to
Nataliia Dudko, Tereza Ilcikova, Natalie Novotna, Marta Czernik, Pasqualino Loi, Josef Fulka Jr., Pritha Bhattacharjee, Raffaella Santoro, Helena Fulka   +8 more
wiley   +1 more source

ATRX: From Chromatin Remodeling to Disease. [PDF]

Genesis
ABSTRACT Chromatin remodeling proteins are evolutionarily conserved factors involved in a wide range of biological processes. In this review, we describe ATRX, a chromatin remodeling protein belonging to the SWI/SNF2 family. Its association with different protein complexes, and its roles in embryonic development, sexual differentiation, as well as ...
Magaña-Acosta M, Valadez-Graham V.
europepmc   +2 more sources

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, EarlyView.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source

Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes

Cell Reports, 2017
How metazoan genomes are structured at the nanoscale in living cells and tissues remains unknown. Here, we adapted a quantitative FRET (Förster resonance energy transfer)-based fluorescence lifetime imaging microscopy (FLIM) approach to assay nanoscale ...
David Llères, Aymeric P. Bailly, Aurélien Perrin, David G. Norman, Dimitris P. Xirodimas, Robert Feil   +5 more
doaj   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. [PDF]

, 2015
Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper,
Briggs, Steven P, Kim, Jinchul, Lee, Pei-Jen, Shen, Zhouxin, Su, Ning-Yuan, Todorova, Dilyana, Xiong, Jianhua, Xu, Yang   +7 more
core  

The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis. [PDF]

Nat Commun, 2022
Mata-Garrido J, Xiang Y, Chang-Marchand Y, Reisacher C, Ageron E, Guerrera IC, Casafont I, Bruneau A, Cherbuy C, Treton X, Dumay A, Ogier-Denis E, Batsché E, Costallat M, Revêchon G, Eriksson M, Muchardt C, Arbibe L.   +17 more
europepmc   +1 more source