Results 151 to 160 of about 1,693,917 (277)

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, EarlyView.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth

Epigenetics & Chromatin, 2018
Background Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes.
Kyohei Oyama, Danny El-Nachef, Chen Fang, Hidemi Kajimoto, Jeremy P. Brown, Prim B. Singh, W. Robb MacLellan   +6 more
doaj   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism

Genome Biology, 2011
BackgroundHeterochromatin protein 1 (HP1) family proteins have a well-characterized role in heterochromatin packaging and gene regulation. Their function in organismal development, however, is less well understood.
P. Meister, Sonia Schott, Cecile Bedet, Yue-Hu Xiao, S. Rohner, Séléna Bodennec, Bruno Hudry, L. Molin, F. Solari, S. Gasser, F. Palladino   +10 more
semanticscholar   +1 more source

Roles of TIF1β in Leukemic Stem Cell Through SETDB1‐Dependent and Independent Mechanisms

Cancer Science, EarlyView.
In leukemic stem cell, BCR::ABL cooperates with TIF1β to open chromatin at oncogenes and close chromatin at differentiation regulators, driving leukemic reprogramming. In TIF1β‐deficient stem cell, the loss of TIF1β inverts this balance, showing closed chromatin at oncogenes and open chromatin at differentiation regulators.
Mariko Morii, Sho Kubota, Goro Sashida
wiley   +1 more source

Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes

Cell Reports, 2017
How metazoan genomes are structured at the nanoscale in living cells and tissues remains unknown. Here, we adapted a quantitative FRET (Förster resonance energy transfer)-based fluorescence lifetime imaging microscopy (FLIM) approach to assay nanoscale ...
David Llères, Aymeric P. Bailly, Aurélien Perrin, David G. Norman, Dimitris P. Xirodimas, Robert Feil   +5 more
doaj   +1 more source

Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1

European Journal of Cell Biology, 2006
Actin-related proteins (Arps) were recently shown to contribute to the organization and regulation of chromatin structures. The nuclear functions of Arps have been investigated principally in budding yeast in which six of the ten Arp subfamilies are localized in the nucleus.
Eri, Ohfuchi, Megumi, Kato, Mitsuho, Sasaki, Kenji, Sugimoto, Yukako, Oma, Masahiko, Harata   +5 more
openaire   +2 more sources

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

The Ca2+ Channel β4c Subunit Interacts with Heterochromatin Protein 1 via a PXVXL Binding Motif*

Journal of Biological Chemistry, 2011
The β subunits of voltage-gated Ca2+ channels are best known for their roles in regulating surface expression and gating of voltage-gated Ca2+ channel α1 subunits.
Xingfu Xu, Y. J. Lee, Johanna B Holm, M. D. Terry, R. Oswald, W. Horne   +5 more
semanticscholar   +1 more source

Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. [PDF]

, 2015
Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper,
Briggs, Steven P, Kim, Jinchul, Lee, Pei-Jen, Shen, Zhouxin, Su, Ning-Yuan, Todorova, Dilyana, Xiong, Jianhua, Xu, Yang   +7 more
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