Results 161 to 170 of about 1,693,917 (277)
Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition
The FEBS Journal, EarlyView.Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis +9 more
wiley +1 more source
PLoS Pathogens, 2009 Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses ...
Christian Flueck +11 more
semanticscholar +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Chromatin organization changes during the establishment and maintenance of the postmitotic state
Epigenetics & Chromatin, 2017 Background Genome organization changes during development as cells differentiate. Chromatin motion becomes increasingly constrained and heterochromatin clusters as cells become restricted in their developmental potential.
Yiqin Ma, Laura Buttitta
doaj +1 more source
The FEBS Journal, EarlyView.Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal +8 more
wiley +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in Xenopus. [PDF]
Dev Dyn, 2021 Tien CL, Mohammadparast S, Chang C.
europepmc +1 more source
Journal of Fish Biology, EarlyView.Abstract Blue‐eyed red‐fin pleco Hypostomus soniae (family Loricariidae) presented a putative sex system XX/XY in early stage. Aiming to explore the inter‐populational karyotypic variation and proposed emergence of the XX/XY system, we studied 13 H. soniae individuals (6 males, 7 females) from the Tapajós River.
Luan Aércio Melo Maciel +6 more
wiley +1 more source
The environmentally responsive plant epigenome: insights from jasmonate signaling
New Phytologist, EarlyView.Summary The environmental responsiveness of the plant epigenome is essential for spatiotemporally precise gene regulation, enabling plants to adapt to external cues. Elucidating the mechanisms underlying this responsiveness is therefore fundamental to deciphering the molecular logic of plant‐environment interactions.
Mark Zander, Emily Vesper
wiley +1 more source
Cell Reports: MethodsSummary: The heterochromatin protein HP1α (heterochromatin protein 1 alpha) phase separates in vitro and displays properties compatible with phase separation in cells.
Ziling (Kate) Zhou +3 more
doaj +1 more source