Results 241 to 250 of about 1,693,917 (277)

Heterochromatin protein 1 binds transgene arrays

Chromosoma, 1998
Heterochromatin protein 1 (HP1) of Drosophila and its homologs in vertebrates are key components of constitutive heterochromatin. Here we provide cytological evidence for the presence of heterochromatin within a euchromatic chromosome arm by immunolocalization of HP1 to the site of a silenced transgene repeat array.
FANTI, Laura, Douglas R. Dorer, Maria Berloco, Steven Henikoff, PIMPINELLI, Sergio   +4 more
openaire   +3 more sources

Heterochromatin protein 1: a pervasive controlling influence

Cellular and Molecular Life Sciences, 2005
Heterochromatin protein 1 (HP1), a component of condensed chromatin, was discovered more than 10 years ago and subsequently found to play important roles in chromosomal biology and gene silencing. Consistent with the hypothesis that post-translational modifications of histones may functionally 'mark' DNA sequences, HP1 was found to bind to 'silent ...
K, Hiragami, R, Festenstein
openaire   +2 more sources

Schistosoma mansoni Heterochromatin Protein 1 (HP1) nuclear interactome in cercariae

Journal of Proteomics, 2021
Schistosoma mansoni causes schistosomiasis, which affects 240 million people, and 700 million people are living at risk of infection. Epigenetic mechanisms are important for transcriptional control and are well-known conserved transcriptional co-regulators in evolution, already described in mammal, yeast, protozoa and S.
Natália Silva, da Trindade, Thaís Cunha, de Sousa Cardoso, Giulliana Galdini, Costa, Gabriela Freitas, Cruvinel, Ana Paula, Masson, Guilherme Pauperio, Lanfredi, Silmara Marques, Allegretti, Vitor, Faça, Matheus, de Souza Gomes, Enyara Rezende, Morais, Fernanda Janku, Cabral   +10 more
openaire   +2 more sources

A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin

Cytogenetic and Genome Research, 1994
The <i>Drosophila</i> HP1 gene contains a highly conserved sequence, the chromobox, which can be used to isolate HP1-like genes from both mouse (M31 and M32) and man (HSM1) (Singh et al., 1991). Here we report that a monoclonal antibody (MoAb) raised against the M31 protein recognises a 26-kDa protein in murine and human nuclear extracts ...
K A, Wreggett, F, Hill, P S, James, A, Hutchings, G W, Butcher, P B, Singh   +5 more
openaire   +2 more sources

Multiple Roles for Heterochromatin Protein 1 Genes inDrosophila

Annual Review of Genetics, 2009
Heterochromatin is the gene-poor, transposon-rich, late-replicating chromatin compartment that was first cytologically defined more than 70 years ago. The identification of heterochromatin protein 1 (HP1) paved the way for a molecular dissection of this important component of complex eukaryotic genomes.
Danielle, Vermaak, Harmit S, Malik
openaire   +2 more sources

Gene regulation by human orthologs of Drosophila heterochromatin protein 1

Biochemical and Biophysical Research Communications, 2002
Heterochromatin protein 1 (HP1) functions in gene silencing, transcriptional regulation, and chromatin remodeling. Drosophila HP1 enhances position effect variegation and has also been shown to repress transcription of some euchromatic genes and activate some heterochromatic ones.
Kyu-Kye, Hwang, Howard J, Worman
openaire   +2 more sources

Heterochromatin protein 1: don’t judge the book by its cover!

Current Opinion in Genetics & Development, 2006
The name heterochromatin protein 1 (HP1) suggests that this small nuclear factor plays a role in forming heterochromatic domains. It was noticed years ago, however, that the distribution of HP1 on polytene chromosomes was not restricted to chromocenters or telomeres. HP1 was also found, reproducibly, along the euchromatic arms.
Florence, Hediger, Susan M, Gasser
openaire   +2 more sources

Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells

Science, 2003
Heterochromatin protein 1 (HP1β), a key component of condensed DNA, is strongly implicated in gene silencing and centromeric cohesion. Heterochromatin has been considered a static structure, stabilizing crucial aspects of nuclear organization and prohibiting access to transcription factors.
Richard, Festenstein, Stamatis N, Pagakis, Kyoko, Hiragami, Debbie, Lyon, Alain, Verreault, Belaid, Sekkali, Dimitris, Kioussis   +6 more
openaire   +2 more sources

DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing

Nature, 2003
Gene repression is crucial to the maintenance of differentiated cell types in multicellular organisms, whereas aberrant silencing can lead to disease. The organization of DNA into chromatin and heterochromatin is implicated in gene silencing. In chromatin, DNA wraps around histones, creating nucleosomes.
Alexander, Saveliev, Christopher, Everett, Tammy, Sharpe, Zoë, Webster, Richard, Festenstein   +4 more
openaire   +2 more sources

Human autoimmune sera recognize a conserved 26 kD protein associated with mammalian heterochromatin that is homologous to heterochromatin protein 1 ofDrosophila

Chromosome Research, 1994
Immunofluorescence indicated that autoimmune sera from certain scleroderma/CREST patients, in addition to binding to the primary constrictions or centromeres, also labelled pericentromeric heterochromatin in mouse and human metaphase chromosomes. Immunoblotting has revealed that two conserved nuclear antigens are recognized by this CREST subgroup, one ...
L, Nicol, P, Jeppesen
openaire   +2 more sources