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Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assemblyopenaire
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Heterochromatin protein 1: a pervasive controlling influence
Cellular and Molecular Life Sciences, 2005Heterochromatin protein 1 (HP1), a component of condensed chromatin, was discovered more than 10 years ago and subsequently found to play important roles in chromosomal biology and gene silencing. Consistent with the hypothesis that post-translational modifications of histones may functionally 'mark' DNA sequences, HP1 was found to bind to 'silent ...
K, Hiragami, R, Festenstein
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Heterochromatin protein 1 binds transgene arrays
Chromosoma, 1998Heterochromatin protein 1 (HP1) of Drosophila and its homologs in vertebrates are key components of constitutive heterochromatin. Here we provide cytological evidence for the presence of heterochromatin within a euchromatic chromosome arm by immunolocalization of HP1 to the site of a silenced transgene repeat array.
FANTI, Laura +4 more
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Cytogenetic and Genome Research, 1994
The <i>Drosophila</i> HP1 gene contains a highly conserved sequence, the chromobox, which can be used to isolate HP1-like genes from both mouse (M31 and M32) and man (HSM1) (Singh et al., 1991). Here we report that a monoclonal antibody (MoAb) raised against the M31 protein recognises a 26-kDa protein in murine and human nuclear extracts ...
K A, Wreggett +5 more
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The <i>Drosophila</i> HP1 gene contains a highly conserved sequence, the chromobox, which can be used to isolate HP1-like genes from both mouse (M31 and M32) and man (HSM1) (Singh et al., 1991). Here we report that a monoclonal antibody (MoAb) raised against the M31 protein recognises a 26-kDa protein in murine and human nuclear extracts ...
K A, Wreggett +5 more
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Analysis of the heterochromatin protein 1 (HP1) interactome in Drosophila
Journal of Proteomics, 2014Heterochromatin protein 1 (HP1) was first described in Drosophila melanogaster as a heterochromatin associated protein required for epigenetic gene silencing. Most eukaryotes have at least three HP1 homologs that play differential roles in heterochromatin and euchromatin.
Hyun-Wook Ryu +5 more
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Function of heterochromatin protein 1 during DNA repair
Protoplasma, 2017This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin, and HP1α and HP1β in particular are responsible for ...
Eva, Bártová +6 more
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Multiple Roles for Heterochromatin Protein 1 Genes inDrosophila
Annual Review of Genetics, 2009Heterochromatin is the gene-poor, transposon-rich, late-replicating chromatin compartment that was first cytologically defined more than 70 years ago. The identification of heterochromatin protein 1 (HP1) paved the way for a molecular dissection of this important component of complex eukaryotic genomes.
Danielle, Vermaak, Harmit S, Malik
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Schistosoma mansoni Heterochromatin Protein 1 (HP1) nuclear interactome in cercariae
Journal of Proteomics, 2021Schistosoma mansoni causes schistosomiasis, which affects 240 million people, and 700 million people are living at risk of infection. Epigenetic mechanisms are important for transcriptional control and are well-known conserved transcriptional co-regulators in evolution, already described in mammal, yeast, protozoa and S.
Natália Silva, da Trindade +10 more
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The Heterochromatin Protein 1 Family is Regulated in Prostate Development and Cancer
Journal of Urology, 2008The HP1 family of evolutionarily conserved proteins regulates heterochromatin packaging, in addition to a less defined role in the regulation of euchromatic genes. To examine the possible role of HP1 proteins in fetal prostate development and prostate cancer the protein expression of HP1alpha, beta and gamma was evaluated in human archival tissue ...
Ellen, Shapiro +5 more
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