Results 51 to 60 of about 58,285 (293)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Stereoselectively fluorinated N-heterocycles: a brief survey

Beilstein Journal of Organic Chemistry, 2013
The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties.
Xiang-Guo Hu, Luke Hunter
doaj   +1 more source

Polar Lattice‐Distorted Motifs Enable Synergy of Local Polarization/Dipole Fields for Concurrent Glyphosate Wastewater Remediation and CO Evolution

Advanced Science, EarlyView.
Photocatalytic treatment of glyphosate herbicide in agricultural wastewater is achieved through the cooperative effect of the local polarization field and dipole field mediated by lattice‐distorted carbon nitride. Glyphosate is completely degraded via selective C─P bond cleavage with a CO evolution rate of 1166 µmol g−1 h−1.
Daoping Chen, Huan Liu, Tengyu Liu, Jie Li, Qizhi Luo, Yan Zhang, Shengkun Li, Hu Li   +7 more
wiley   +1 more source

Divergent synthesis of N-heterocycles via controllable cyclization of azido-diynes catalyzed by copper and gold

Nature Communications, 2017
Fused N-heterocycles are structural motifs observed in natural products and bioactive compounds. Here, the authors developed divergent copper- and gold-catalyzed oxidative cyclizations of diynes to two types of tricyclic N-heterocycles and rationalized ...
Wen-Bo Shen, Qing Sun, Long Li, Xin Liu, Bo Zhou, Juan-Zhu Yan, Xin Lu, Long-Wu Ye   +7 more
doaj   +1 more source

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

Covalent Bonds Reinforced Strength and Modulus of Heterocyclic Aramid Fiber by Interfacial Aminated‐MXene Nanosheets

Advanced Science, EarlyView.
We demonstrate the covalent bonds strategy to enhance the mechanical property of PBIA fiber by using interfacial MXene‐NH2 nanosheets. The MXene‐NH2 nanosheets with reactive amino sites that can serve as nucleating agents and chain anchors to enhance orientation, crystallinity and interchain interaction of PBIA fiber via strong interfacial amido ...
Boyuan Chen, Hansheng Liu, Weiheng Kong, Ke Han, Jing Fang, Xingjiang Wu, Jianhong Xu, Hao Li   +7 more
wiley   +1 more source

Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles

ChemistryOpen
Heterocycles are a vital class of compounds in numerous fields, including drug discovery, agriculture, and materials science. Efficient methods for the synthesis of heterocycles remain critical for meeting the demands of these industries. Recent advances
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi, Peter J. Jervis   +3 more
doaj   +1 more source

Recent Discovery of Nitrogen Heterocycles from Marine-Derived Aspergillus Species

Marine Drugs
Nitrogen heterocycles have drawn considerable attention because of their structurally novel and significant biological activities. Marine-derived fungi, especially the Aspergillus species, possess unique metabolic pathways to produce secondary ...
Jueying Shi, Miao Yu, Weikang Chen, Shiji Chen, Yikang Qiu, Zhenyang Xu, Yi Wang, Guolei Huang, Caijuan Zheng   +8 more
doaj   +1 more source

Substrate‐Affinitive P‐Type Azapolycyclic Photosensitizer for Chemoselective Nitrilization Under Mild Conditions

Advanced Science, EarlyView.
We developed a series of quinoxalinoquinoxaline (QQ) photosensitizers featuring high and tunable excited‐state reduction potentials (E(PC•+/PC*) = –1.76 to –2.05 V vs. SCE). Their hydrogen‐bonding interaction with carbonyl substrates enables selective single‐electron transfer events for selective nitrilization of 1° amides, offering a tunable ...
Seongwoo Bae, Dongwook Kim, Jinwoo Kim
wiley   +1 more source