Results 61 to 70 of about 101,033 (289)

Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles

Nature Communications, 2021
Late-stage C(sp3)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here the authors show copper-catalysed late-stage C(sp3)-
Zhe Chang, Jialin Huang, Si Wang, Geshuyi Chen, Heng Zhao, Rui Wang, Depeng Zhao   +6 more
doaj   +1 more source

Shaping Carbon Nitrides for Advanced Macrostructures

Advanced Materials Technologies, EarlyView.
This review examines how carbon nitride can be shaped through a range of printing and interfacial assembly methods. By bringing together additive manufacturing and liquid–liquid structuring concepts, carbon nitride is moving beyond its traditional powder‐based photocatalyst form toward digitally designed robust macroscale architectures with high design
Simona Baluchová, Baris Kumru
wiley   +1 more source

Chemical characterization of liquefaction products of an inertinite enriched northern Alaska coals [PDF]

, 1989
A Northern Alaskan coal rich in inertinites was further enriched by density gradient separations. The degree of condensation of the enriched coal was estimated to be low, mainly 3 ring.
Mayasandra, Venugopal
core  

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Stereoselectively fluorinated N-heterocycles: a brief survey

Beilstein Journal of Organic Chemistry, 2013
The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties.
Xiang-Guo Hu, Luke Hunter
doaj   +1 more source

Phosphine-Catalyzed Annulations of Azomethine Imines: Allene-Dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] Pathways [PDF]

, 2011
In this paper we describe the phosphine-catalyzed [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] annulations of azomethine imines and allenoates. These processes mark the first use of azomethine imines in nucleophilic phosphine catalysis, producing ...
Benitez, Diego, Goddard, William A., III, Guo, Hongchao, Jiang, Hui, Jing, Chengfeng, Kwon, Ohyun, Na, Risong, Shi, Jiayan, Tkatchouk, Ekaterina, Wang, Min, Wu, Xi, Xu, Qihai, Zhong, Jiangchun   +12 more
core   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Divergent synthesis of N-heterocycles via controllable cyclization of azido-diynes catalyzed by copper and gold

Nature Communications, 2017
Fused N-heterocycles are structural motifs observed in natural products and bioactive compounds. Here, the authors developed divergent copper- and gold-catalyzed oxidative cyclizations of diynes to two types of tricyclic N-heterocycles and rationalized ...
Wen-Bo Shen, Qing Sun, Long Li, Xin Liu, Bo Zhou, Juan-Zhu Yan, Xin Lu, Long-Wu Ye   +7 more
doaj   +1 more source

Transfer of electrophilic NH using convenient sources of ammonia: direct synthesis of N–H sulfoximines from sulfoxides [PDF]

, 2016
The transfer of nitrogen atoms is extremely valuable in the preparation of medicinal compounds. Here, a new system for NH transfer is developed to prepare sulfoximines, which are emerging as valuable motifs for drug discovery.
Bentley, Bizet, Bizet, Buglioni, Carroccia, Cheng, Collins, Collins, Collins, Dauban, Degennaro, Dohi, Dong, Fiori, Goldberg, Gutmann, Iacobucci, Ivanov, Jat, Johnson, Langner, Lücking, Lücking, Mancheño, Mendiola, Miao, Miyasaka, Ochiai, Okamura, Rit, Roizen, Romero, Shen, Silva, Souto, Starkov, Tamura, Teng, Wang, Weber, Williamson, Zenzola, Zhu, Zou   +43 more
core   +1 more source

Dibenzonaphthyridinones: Heterocycle-to-Heterocycle Synthetic Strategies and Photophysical Studies [PDF]

Organic Letters, 2015
A heterocycle-to-heterocycle strategy is presented for the preparation of highly fluorescent and solvatochromic dibenzonaphthyridinones (DBNs) via methodology that leads to the formation of a tertiary, spiro-fused carbon center. A linear correlation between the results of photophysical experiments and time dependent density functional theory ...
Palazzo, Teresa A, Patra, Digambara, Yang, Joung S, Khoury, Elsy El, Appleton, Mackenzie G, Haddadin, Makhluf J, Tantillo, Dean J, Kurth, Mark J   +7 more
openaire   +4 more sources