Results 141 to 150 of about 78,399 (204)

Electrocatalytic Polarity Inversion of Azlactones: Access to α‐Quaternary Amino Acids with Electron‐Rich SOMOphiles

Angewandte Chemie, EarlyView.
Electrocatalytic polarity inversion of azlactones unlocks their coupling with electron‐rich reaction partners. Triarylamine‐mediated oxidation of the azlactone enolate generates an electrophilic radical intermediate that undergoes selective C4 functionalization with diverse SOMOphiles.
Paula Rodríguez, David Buedo, Alberto Vega‐Peñaloza, Kian Gosling, Stuart C. D. Kennington, Bart Limburg, Xavier Companyó   +6 more
wiley   +1 more source

Reaction of barbituric acid with organic azides and phosphonium ylides

Open Chemistry, 2013
Lebedyeva Iryna, Sileno Sean, Patel Kunal, Ghiviriga Ion, Steel Peter, Katritzky Alan   +5 more
doaj   +1 more source

Novel Heterocyclic Compounds as SMN2 Modulators for Treating Spinal Muscular Atrophy Via Modulation of SMN2 Splicing. [PDF]

ACS Med Chem Lett
Sabnis RW.
europepmc   +1 more source

Sustainable Access to N‐Heterocycles: One‐Pot Cascade Synthesis of Pyrroles From Bio‐Derived Furans

Angewandte Chemie, EarlyView.
Highly dispersed platinum (Pt) clusters on Brønsted acid‐rich HY zeolite enable a one‐pot cascade conversion of bio‐derived furans and nitroarenes into pyrroles. Highly dispersed Pt sites ensure selective nitro hydrogenation, while Pt nanoparticles promote undesired over‐hydrogenation.
Haifeng Qi, Germán López Robledo, Jianglin Duan, Yujing Ren, Kathrin Junge, Matthias Beller   +5 more
wiley   +1 more source

Therapeutic Role of Heterocyclic Compounds in Neurodegenerative Diseases: Insights from Alzheimer's and Parkinson's Diseases. [PDF]

Neurol Int
Puranik N, Song M.
europepmc   +1 more source

NHC‐Copper(I)‐Mediated Functionalization of White Phosphorus

Angewandte Chemie, EarlyView.
White phosphorus is functionalized by N‐heterocyclic carbene supported copper(I) complexes through redox‐neutral steps. Treatment of the resulting complexes with electrophiles releases the ligands from the metal center as asymmetrically substituted organophosphorus butterfly compounds.
Thomas M. Horsley Downie, Sophia A. Vogler, Gábor Balázs, Francesco Cirigliano, Robert Wolf   +4 more
wiley   +1 more source

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, EarlyView.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +1 more source

Novel Bicyclic Heterocyclic Compounds as CD73 Inhibitors for Treating Cancer. [PDF]

ACS Med Chem Lett
Sabnis RW.
europepmc   +1 more source

1,2‐Bis(boronate) Arenes by Borylation Directed Borylation

Angewandte Chemie, EarlyView.
Boron electrophiles derived from tetrabromo‐pyrazaboles and AlCl3 affect the regioselective vicinal double C–H borylation of a range of arenes and polycyclic aromatic hydrocarbons (PAHs). A subsequent pinacol installation step then affords the vicinal bis‐boronate ester‐substituted arene/PAH.
Anna V. Schellbach, Mathew J. Cross, Emily Noone, Cate S. Anstöter, Michael J. Ingleson   +4 more
wiley   +1 more source

Recent Developments in the Metal-Catalyzed Synthesis of Nitrogenous Heterocyclic Compounds. [PDF]

Molecules
Zhang X, Bi W, Cao Z, Shen J, Chen B.
europepmc   +1 more source