Results 121 to 130 of about 23,910,082 (307)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A Statistical Analysis of Heterogeneity on Labour Markets and Unemployment Rates in Colombia

, 2015
In this paper, we study the structural factors that determine the differences in unemployment rates and in labour market performance for Colombian cities.
Jhon Edwar Torres Gorron, Camilo Alberto Cárdenas Hurtado, María Alejandra Hernández Montes   +2 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Effects of Japanese Interventions on FX-Forecast Heterogeneity [PDF]

This paper investigates the determinants of forecast heterogeneity in the Yen-US dollar market using a panel data set from Consensus Economics. Regardless of the particular model specification and consideration of control variables we find that exchange ...
Reitz, Stefan, Taylor, Mark P., Stadtmann, Georg   +2 more
core  

Imaging System for Plant Photosynthetic Phenotypes Incorporating Three-dimensional Structured Light and Chlorophyll Fluorescence

智慧农业
ObjectiveThe investigation of plant photosynthetic phenotypes is essential for unlocking insights into plant physiological characteristics and dissecting morphological traits.
SHU Hongwei, WANG Yuwei, RAO Yuan, ZHU Haojie, HOU Wenhui, WANG Tan   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The Diversity of Capitalism and Heterogeneity of Firms - A Case Study of Japan during the Lost Decade [PDF]

Most institutional theories of the diversity of capitalism (at least implicitly) assume the existence of a representative firm in each type of capitalism.
Sébastien Lechevalier
core  

Research on Spatial Heterogeneity, Impact Mechanism, and Carbon Peak Prediction of Carbon Emissions in the Yangtze River Delta Urban Agglomeration

Energies
Urban agglomerations with a high economic activity and population density are key areas for carbon emissions and pioneers in achieving carbon peaking and the Sustainable Development Goals (SDGs).
Pin Chen, Xiyue Wang, Zexia Yang, Changfeng Shi   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source