Results 181 to 190 of about 23,910,082 (307)

Reporting Heterogeneity in Self-Assessed Health among Elderly Europeans: The Impact of Mental and Physical Health Status [PDF]

Self-assessed health (SAH) is a frequently used measure of individuals’ health status. It is also prone to reporting heterogeneity. To control for reporting heterogeneity valid measures of the objective health status are needed.
Schmid, Andreas, Pfarr, Christian, Schneider, Udo   +2 more
core  

Interpretable machine learning framework for urban flood susceptibility assessment: a multi-model comparison with spatial heterogeneity analysis in Yancheng. [PDF]

Sci Rep
Zhang X, Guo D.
europepmc   +1 more source

Spatial Transcriptomics for Tumor Heterogeneity Analysis. [PDF]

Front Genet, 2022
Li Q, Zhang X, Ke R.
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Incorporating prior information in gene expression network-based cancer heterogeneity analysis. [PDF]

Biostatistics
Li R, Xu S, Li Y, Tang Z, Feng D, Cai J, Ma S.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Comparative Mortality Risk of Aripiprazole, Olanzapine, Quetiapine, and Risperidone in Alzheimer's Disease: A Real‑World Retrospective Cohort Study with Treatment Effect Heterogeneity Analysis. [PDF]

CNS Drugs
Jiang C, Krivinko J, Yu Z, Sweet RA, Zeng L, Wang H, Ding Y, Zeng Z, Kofler J, Wang L.   +9 more
europepmc   +1 more source

Local heterogeneity analysis of crystallographic and cryo-EM maps using shell-approximation. [PDF]

Curr Res Struct Biol, 2023
Lunin VY, Lunina NL, Urzhumtsev AG.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Heterogeneity Analysis of Associations Involving the Large-Scale Online MindCrowd Survey Memory Test. [PDF]

Gerontology
Bhadra N, Don J, De Both M, Johnson M, Sharma S, Chambers D, Huentelman M, Schork NJ.   +7 more
europepmc   +1 more source