Results 81 to 90 of about 38,755 (208)

Viral immune modulators perturb the human molecular network by common and unique strategies [PDF]

, 2012
Viruses must enter host cells to replicate, assemble and propagate. Because of the restricted size of their genomes, viruses have had to evolve efficient ways of exploiting host cell processes to promote their own life cycles and also to escape host ...
Bürckstümmer, Tilmann, R. Sacco, Goodbourn, S., Kandasamy, Kumaran, Friedemann Weber, Matthias Habjan, A. Fauster, Eberle, Carol-Ann, Burckstummer, T., Weber, F., Mulhern, Orla, Colinge, Jacques, Bartenschlager, Ralf, Muller, A. C., Fauster, A., Bowie, A. G., Alvisi, G., O. Mulhern, Holze, Cathleen, Holze, C., Fauster, Astrid, Andrew G. Bowie, A. Pichlmair, Kochs, Georg, Ralf Bartenschlager, Tilmann Bürckstümmer, Superti-Furga, G., M. Binder, Habjan, Matthias, Bennett, K. L., Goncalves, A., Adriana Goncalves, Kristina Lindsten, Superti-Furga, Giulio, S. Goodbourn, A. Stefanovic, R. Bartenschlager, C. A. Eberle, Pichlmair, A., Stefanovic, Adrijana, Astrid Fauster, M. Habjan, Roberto Sacco, K. L. Bennett, Stephen Goodbourn, T. Bürckstümmer, G. Superti Furga, André C. Müller, Bartenschlager, R., Habjan, M., Marco Binder, Bowie, Andrew G., Gualtiero Alvisi, A. C. Müller, A. Goncalves, Kandasamy, K., Weber, Friedemann, Bennett, Keiryn L., G. Kochs, Müller, André C., Giulio Superti-Furga, Pichlmair, Andreas, Sacco, R., Binder, M., Cathleen Holze, Georg Kochs, Binder, Marco, K. Kandasamy, J. Colinge, Lindsten, K., Eberle, C. A., Mulhern, O., Goncalves, Adriana, ALVISI, GUALTIERO, C. Holze, Sacco, Roberto, Goodbourn, Stephen, F. Weber, Kumaran Kandasamy, Carol-Ann Eberle, Keiryn L. Bennett, K. Lindsten, Andreas Pichlmair, A. G. Bowie, Adrijana Stefanovic, Orla Mulhern, Lindsten, Kristina, Colinge, J., Jacques Colinge, Kochs, G., Stefanovic, A.   +90 more
core   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Cancer Science, EarlyView.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang, Tianli Zhang, Xue Kong, Yao Tong, Yanru Li, Xiangjun Dong, Chuanxin Wang, Juan Li   +7 more
wiley   +1 more source

DNA Damage-induced Heterogeneous Nuclear Ribonucleoprotein K SUMOylation Regulates p53 Transcriptional Activation*

Journal of Biological Chemistry, 2012
Background: hnRNP K acts as a p53 cofactor upon DNA damage. Results: DNA damage stimulates hnRNP K sumoylation, and this modification is required for p53 target gene expression.
Federico Pelisch, B. Pozzi, Guillermo J. Risso, M. Muñoz, Anabella Srebrow   +4 more
semanticscholar   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Splice site strength–dependent activity and genetic buffering by poly-G runs [PDF]

, 2009
Pre-mRNA splicing is regulated through the combinatorial activity of RNA motifs, including splice sites and splicing regulatory elements. Here we show that the activity of the G-run (polyguanine sequence) class of splicing enhancer elements is approx4 ...
Eric T Wang, Wang, Zefeng, Zefeng Wang, Minyoung Jang, Razvan Nutiu, Xiao, Xinshu, Jang, Minyoung, Nutiu, Razvan, Burge, Christopher B, Xinshu Xiao, Christopher B Burge, Wang, Eric T   +11 more
core   +1 more source

The C-group Heterogeneous Nuclear Ribonucleoprotein Proteins Bind to the 5′ Stem-Loop of the U2 Small Nuclear Ribonucleoprotein Particle*

Journal of Biological Chemistry, 1996
The C-group heterogeneous nuclear ribonucleoprotein (hnRNP) proteins bind to nascent pre-messenger RNA. In vitro studies have indicated that the C hnRNP proteins bind particularly strongly to the intron polypyrimidine tract of pre-mRNA and may be ...
J. Temsamani, T. Pederson
semanticscholar   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer, Giuseppina De Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source

Optimized RNA Targets of Two Closely Related Triple KH Domain Proteins, Heterogeneous Nuclear Ribonucleoprotein K and αCP-2KL, Suggest Distinct Modes of RNA Recognition*

Journal of Biological Chemistry, 2001
The KH domain mediates RNA binding in a wide range of proteins. Here we investigate the RNA-binding properties of two abundant RNA-binding proteins, αCP-2KL and heterogeneous nuclear ribonucleoprotein (hnRNP) K. These proteins constitute the major poly(C)
T. Thisted, D. L. Lyakhov, S. Liebhaber
semanticscholar   +1 more source

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

Internal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar, Jun Yen Ng, Adam Bryant, Annmarie Bosco, Hugh C. Caterson, Pratyush Giri, Pravin Hissaria, Simon J. Harrison, Stephen Lade, Connull Leslie, Jacinta Perram, H. Miles Prince, Dejan Radeski, Maureen Rischmueller, Craig Wallington‐Gates, Nicholas Weber, Alberta Hoi   +16 more
wiley   +1 more source

Heterogeneous Nuclear Ribonucleoprotein F/H Proteins Modulate the Alternative Splicing of the Apoptotic Mediator Bcl-x*

Journal of Biological Chemistry, 2005
Bcl-x is a member of the Bcl-2 family of proteins that are key regulators of apoptosis. The Bcl-x pre-mRNA is alternatively spliced to yield Bcl-xS and Bcl-xL, two isoforms that have been associated, respectively, with the promotion and the prevention of
D. Garneau, T. Revil, Jean-François Fisette, B. Chabot   +3 more
semanticscholar   +1 more source