Results 61 to 70 of about 38,755 (208)

Heterogeneous nuclear ribonucleoprotein C1 may control miR-30d levels in endometrial exosomes affecting early embryo implantation

Molecular human reproduction, 2018
STUDY QUESTION Is there a specific mechanism to load the microRNA (miRNA), hsa-miR-30d, into exosomes to facilitate maternal communication with preimplantation embryos? SUMMARY ANSWER The heterogeneous nuclear ribonucleoprotein C1 (hnRNPC1) is involved
N. Balaguer, Inmaculada Moreno, María Herrero, M. Gonzalez, Carlos Simón, F. Vilella   +5 more
semanticscholar   +1 more source

Translational Gap in Biomarker Discovery: Tumor Surface Markers Rarely Mirror Circulating Levels

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Tumor‐associated cell surface proteins are frequently proposed as circulating biomarkers for colorectal cancer (CRC) based on their high tumor expression. However, many candidates identified through tissue‐based analyses fail to translate into clinically useful biomarkers.
Junko Mukohyama, Shohei F. Fujita, Xinyi Fu, Shigenori Suzuki, Hiroki Hamamoto, Dai Shida, Kimihiro Yamashita, Kohei Taniguchi, Sang‐Woong Lee, Akihide Yoshimi   +9 more
wiley   +1 more source

The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. [PDF]

, 1994
A series of in vitro protein-RNA binding studies using purified native (C1)3C2 and (A2)3B1 tetramers, total soluble heterogeneous nuclear ribonucleoprotein (hnRNP), and pre-mRNA molecules differing in length and sequence have revealed that a single C ...
Lestourgeon, W. M., Mayeda, A., Rech, J. E., Northington, S. J., Krainer, A. R., Flicker, P. F., Huang, M.   +6 more
core  

Lost in translation : The biogenesis of non-LTR retrotransposon proteins [PDF]

, 2013
This research was supported by UK Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust.“Young” APE-type non-LTR retrotransposons (non-LTRs) typically encode two open reading frames (ORFs 1 and 2).
Roulston, Claire, Odon, Valerie, Odon, V, de Felipe, Pablo, Sukhodub, Andriy, Ryan, MD, Ryan, Martin Denis, Roulston, C, Luke, GA, de Felipe, P, Sukhodub, A, Luke, Garry Alec   +11 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae. [PDF]

, 2008
BACKGROUND: Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis.
Laponogov, I, Pan, Xiao-Su, L Mark Fisher, Veselkov, DA, Sanderson, MR, Xiao-Su Pan, Sohi, MK, Mark R Sanderson, Fisher, L. Mark, Sanderson, Mark R., Laponogov, Ivan, Fisher, LM, Dennis A Veselkov, Pan, XS, Maninder K Sohi, Veselkov, Dennis A., Ivan Laponogov, Sohi, Maninder K.   +17 more
core   +1 more source

Solution Structure of the HIV-1 Intron Splicing Silencer and Its Interactions with the UP1 Domain of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1*

Journal of Biological Chemistry, 2015
Splicing patterns in human immunodeficiency virus type 1 (HIV-1) are maintained through cis regulatory elements that recruit antagonistic host RNA-binding proteins. The activity of the 3′ acceptor site A7 is tightly regulated through a complex network of
Niyati Jain, C. E. Morgan, B. Rife, M. Salemi, B. Tolbert   +4 more
semanticscholar   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Cloning and characterization of a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein-like protein and its expression in myeloid leukemia cells [PDF]

, 1998
We isolated a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein on DNA affinity screening of a K562 cDNA expression library with an oligodeoxynucleotide (JKT41) derived from intron 9 of the human myeloperoxidase gene. The
Akira Takano, Takaaki Matsui, Michiyuki Yamada, Naoto Tsuchiya, Daisuke Kamei   +4 more
core  

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. [PDF]

, 2010
International audienceReversible protein phosphorylation has an essential role during pre-mRNA splicing. Here we identify two previously unidentified phosphoproteins in the human spliceosomal B complex, namely the pre-mRNA processing factors PRP6 and ...
Henning Urlaub, Giet, Régis, Marc Schneider, Reinhard Lührmann, Schneider, M., Urlaub, Henning, Hsiao, H., Urlaub, H., Cindy L Will, Régis Giet, Giet, R., Schneider, Marc, Will, C., Will, C. L., He-Hsuan Hsiao, Hsiao, He-Hsuan, Hsiao, H. H., Luehrmann, R., Lührmann, R., Will, Cindy, L., Lührmann, Reinhard   +20 more
core   +1 more source