Results 81 to 90 of about 4,842 (250)
Genetic effects on molecular network states explain complex traits
Molecular Systems Biology, 2023 The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules, but so far ...
Matthias Weith +10 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Modeling Heterogeneous Network Interference [PDF]
, 2012 International audienceCellular systems are becoming more heterogeneous with the introduction of low power nodes including femtocells, relays, and distributed antennas.
Kountouris, Marios +3 more
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Energy efficiency heterogeneous wireless communication network with QoS support [PDF]
, 2013 The overarching goal of this thesis is to investigate network architectures, and find the trade-off between low overall energy use and maintaining the level of quality of service (QoS), or even improve it.
Hou, Ying
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Power-optimised multi-radio network under varying throughput constraints for rural broadband access [PDF]
, 2013 The use of complementary radio access technologies within a network allows the advantages of each technology to be combined to overcome individual limitations.
Weiss, Stephan, McGuire, Colin
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Optical network architectures for dynamic reconfiguration of full duplex, multiwavelength, radio over fiber [PDF]
, 2006 In recent years there have been rapid advances in the techniques to generate and transport radio signals over optical fiber, but very little has been done to date to develop the concept of a full duplex, multiwavelength, radio-over-fiber network ...
J. C. Attard +3 more
core