Results 101 to 110 of about 2,444,541 (290)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Enhancing cybersecurity through autonomous knowledge graph construction by integrating heterogeneous data sources [PDF]
PeerJ Computer ScienceCybersecurity plays a critical role in today’s modern human society, and leveraging knowledge graphs can enhance cybersecurity and privacy in the cyberspace.
Hatoon Alharbi +3 more
doaj +2 more sources
On Measuring the Welfare Gains from Trade Under Consumer Heterogeneity
The Economic Journal, 2015 I develop a multi-country, multi-industry model of trade that features heterogeneous consumers with non-homothetic preferences. I use the model to quantify the measurement errors in the welfare gains estimates caused by the assumption of a representative consumer (ARC).
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Recent Advances in High-Performance Erbium-Doped Waveguide Amplifiers
Guangtongxin yanjiuThe explosive growth in bandwidth demand driven by data centers, the 5th/6th Generation Network (5G/6G) communications, and high-performance computing has made photonic integrated circuits crucial for high-density, low-loss information processing. As key
CHEN Baobao +5 more
doaj
Integrated water resources management (IWRM) for climate change adaptation
, 2017 Water is considered the bloodstream of the biosphere, but its management is one of the most important challenges for human development. In view of the sustainable water management, several approaches have been proposed: Integrated Water Resources ...
Animesh K. Gain +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Spatial Assessment of Risk of River Flood in Dhaka City, Bangladesh
, 2008 Modern water management approaches aim to limit damage by ascertaining risk. Dhaka, the capital city of Bangladesh is surrounded by a network of rivers, which makes the city vulnerable to flooding. After the 1988 flood, the western part of Dhaka City was
Animesh Gain
core