Results 21 to 30 of about 39,672 (250)

Negative feedback scheduling algorithm based on historical information in SDN

网络与信息安全学报, 2018
In the current SDN architecture,the controllers suffer from lots of potential attacks.For example,malicious flow rule attacks may introduce fake flow rules to confuse the host.A negative feedback scheduling algorithm based on historical information was ...
Yingying LYU, Yunfei GUO, Zhenpeng WANG, Guozhen CHENG, Yawen WANG   +4 more
doaj   +3 more sources

Efficient Stochastic Approximation Monte Carlo Sampling for Heterogeneous Redundancy Allocation Problem

IEEE Access, 2016
Existing optimization methods to heterogeneous redundancy allocation problem often suffer from the local-trap problem in optimization, due to the rugged energy landscapes.
Min Xu, Xiuzhuang Zhou, Qirun Huo, Haomin Liu   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Architectural-Space Exploration of Heterogeneous Reliability and Checkpointing Modes for Out-of-Order Superscalar Processors

IEEE Access, 2019
State-of-the-art reliability techniques and mechanisms deploy full-scale redundancy, like double or triple modular redundancy (DMR, TMR), on different layers of the computing stack to detect and/or correct such transient faults.
Bharath Srinivas Prabakaran, Mihika Dave, Florian Kriebel, Semeen Rehman, Muhammad Shafique   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Selection of node with editing rights and privacy protection mechanisms based on dual-blockchain

Journal of King Saud University: Computer and Information Sciences, 2023
The inability to edit and modify the data on the blockchain limits its practical applications. Current editable blockchain schemes with little regard for security in the editing process, and there is a lack of effective monitoring and auditing measures ...
Lin Ge, Tao Jiang, Hongquan Wei
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source