Results 31 to 40 of about 39,672 (250)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Finding Bayesian Nash equilibrium in DHR

Security and Safety
This study presents an effective cybersecurity defense mechanism by integrating the Dynamic Heterogeneous Redundancy (DHR) architecture with advanced algorithmic strategies to combat complex, evolving cyber threats while maintaining system performance ...
Wu Yue, Liu Yu, Chen Ping
doaj   +1 more source

Methods of reliability assessment of heterogeneous redundant systems

IFAC-PapersOnLine, 2016
Abstract Reliability assessment is required for the determination of a safety integrity level (SIL) of safety systems in accordance to the functional safety approach. Functional safety standards suggest formulas for calculating PFD/PFH which numerical values are used for establishing correspondence to the SIL.
Rogova, E.S. (author), Lodewijks, G. (author)   +1 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Heterogeneous executor scheduling algorithm for mimic cloud service

Tongxin xuebao, 2020
At present,most heterogeneous scheduling models were only designed from the perspective of space or time,without comprehensive consideration the characteristics of time and space,and there was a problem of insufficient balance between dynamics and ...
Liming PU, Shuxin LIU, Ruihao DING, Kai WANG   +3 more
doaj   +2 more sources

Pixelated: A Lossless Data Transformation Framework Built on PNG Compression

Algorithms
The rapid growth of digital data has created an urgent need for innovative storage solutions. Transactional data, with its diverse formats and row-based structure, is a significant contributor to this challenge.
Zina Abohaia, Patrick Mukala
doaj   +1 more source

EFFICIENCY OF REDUNDANT SYSTEM THROUGH CONFIGURATION SUPERVISORS

Надежность и качество сложных систем, 2022
Background. The path to the creation of highly reliable equipment, each separate part of which, due to several factors, has limited reliability, is to develop reconfigurable systems with an excessive number of heterogeneous components. The objective of
А.М. Ageev, V.N. Bukov
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Risk-Aware Cost-Constrained Scheduling for Resource- Constrained Dynamic Heterogeneous Redundancy Systems

Computers
Resource-constrained dynamic heterogeneous redundancy (DHR) systems use executor diversity and runtime reconfiguration to reduce stable attack surfaces.
Kexuan Liu, Yanyu Chen, Ying Wang, Yuxiang Zhou, Tao Wan, Xin Xie   +5 more
doaj   +1 more source