Results 261 to 270 of about 361,202 (360)
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann +12 more
wiley +1 more source
Synthetic Biology Strategies for Activating Cryptic BGCs in <i>Streptomyces</i>: Engineering Native and Synthetic Promoters for Antibiotic Discovery. [PDF]
Shil R +4 more
europepmc +1 more source
Heterologous antilymphocyte glubulin, histoincompatiblity matching, and human renal homotransplantation. [PDF]
Brettschneider, L +5 more
core
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi +14 more
wiley +1 more source
Development of convenient potyvirus-based vectors for simultaneous expression of two heterologous proteins in solanaceous plants. [PDF]
Li N +8 more
europepmc +1 more source
The return of metabolism: biochemistry and physiology of glycolysis
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning +19 more
wiley +1 more source
Heterologous prime-boost vaccination with VLA2001 and an ORFV-based vector enhances spike- and nucleocapsid-specific immunity in mice. [PDF]
Reguzova A +6 more
europepmc +1 more source

