Results 31 to 40 of about 1,367 (116)

Self‐Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging

Aging Cell, Volume 25, Issue 1, January 2026.
We report the development and application of a mouse ovarian somatic organoid model to elucidate a fundamental new understanding of the cell biology of the aging ovarian microenvironment. ABSTRACT Ovarian somatic cells are essential for reproductive function, but no existing ex vivo models recapitulate the cellular heterogeneity or interactions within ...
Shweta S. Dipali, Aubrey Converse, Madison Q. Gowett, Pratik Kamat, Emily J. Zaniker, Abigail Fennell, Teresa Chou, Michele T. Pritchard, Mary Zelinski, Jude M. Phillip, Francesca E. Duncan   +10 more
wiley   +1 more source

Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs [PDF]

, 2009
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic synapse development.
Elgoyhen, Ana Belen, Murthy, Vidya, Taranda, Julian, Vetter, Douglas E.   +3 more
core   +1 more source

Discovering Invariant Neighborhood Patterns for Heterophilic Graphs

CoRR
This paper studies the problem of distribution shifts on non-homophilous graphs Mosting existing graph neural network methods rely on the homophilous assumption that nodes from the same class are more likely to be linked. However, such assumptions of homophily do not always hold in real-world graphs, which leads to more complex distribution shifts ...
Yang, Jinluan, Zhang, Ruihao, Chen, Zhengyu, Xiao, Teng, Wang, Yueyang, Wu, Fei, Kuang, Kun   +6 more
openaire   +2 more sources

An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate

Developmental Dynamics, Volume 254, Issue 10, Page 1115-1132, October 2025.
Abstract Background The forces underlying convergence and internalization of the teleost neural plate remain unknown. To help understand this morphogenesis, we analyzed collective and individual cell behaviors at the superficial surface of the neural plate as internalization begins to form the neural keel in the hindbrain region of the zebrafish embryo.
Claudio Araya, Raegan Boekemeyer, Francesca Farlie, Lauren Moon, Freshta Darwish, Chris Rookyard, Leanne Allison, Gema Vizcay‐Barrena, Roland Fleck, Millaray Aranda, Masa Tada, Jonathan D. W. Clarke   +11 more
wiley   +1 more source

Demystifying Structural Disparity in Graph Neural Networks: Can One Size Fit All?

, 2023
Recent studies on Graph Neural Networks(GNNs) provide both empirical and theoretical evidence supporting their effectiveness in capturing structural patterns on both homophilic and certain heterophilic graphs.
Chen, Zhikai, Han, Haoyu, Jin, Wei, Ma, Yao, Mao, Haitao, Shah, Neil, Tang, Jiliang, Zhao, Tong   +7 more
core  

Transcriptional Response of Human Neurospheres to helper-dependent CAV-2 vectors involves the modulation of DNA damage response, microtubule and centromere gene groups [PDF]

, 2015
Brain gene transfer using viral vectors will likely become a therapeutic option for several disorders. Helper-dependent (HD) canine adenovirus type 2 vectors (CAV-2) are well suited for this goal.
Alves, Paula M., Brito, Catarina, Burla, Romina, Kremer, Eric J., La Torre, Mattia, Licursi, Valerio, Mottini, Carla, Negri, Rodolfo, Piersanti, Stefania, Saggio, Isabella, Salinas, Sara, Simao, Daniel, Tagliafico, Enrico   +12 more
core   +5 more sources

Cadherin‐6 controls neuronal migration during mouse neocortical development via an integrin‐mediated pathway

The FEBS Journal, Volume 292, Issue 20, Page 5382-5397, October 2025.
Neuronal migration plays essential roles in the establishment of mammalian brains, and its impairment causes severe developmental abnormalities and behavioral and cognitive deficits. Here, we report that cadherin‐6 (CDH6), an unusual cadherin molecule containing an RGD integrin‐binding motif in the first extracellular domain, controls the motility of ...
Yuki Hirota, Rikaho Saito, Takao Honda, Hitomi Sano, Mayuko Hotta, Yukiko U. Inoue, Takayoshi Inoue, Kazunori Nakajima   +7 more
wiley   +1 more source

SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors [PDF]

, 2014
Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) plays an essential role in the immune system mediating the function of several members of the SLAM family (SLAMF) of receptors, whose expression is essential for T, NK, and B-cell ...
De Calisto, Jaime, Engel, Pablo, Terhorst, Cox, Wang, Guoxing, Wang, Ninghai, Yigit, Burcu   +5 more
core   +3 more sources

The Hunt for HLA‐DQ Allogeneic Eplets Is Not Over: Four New Ones, Including a Cross‐Chain Eplet

HLA, Volume 106, Issue 3, September 2025.
ABSTRACT The target of an anti‐HLA antibody is an epitope on the surface of the antigen, and in particular the polymorphic eplet of its core, which contains one or a few polymorphic residues accessible to the molecule surface. The HLA Eplet Registry database references more than 550 HLA eplets thus deduced from AA sequence alignments.
Magali Devriese, Diego Amaya‐Ramirez, Tina Meng, Hiroko Miyadera, Lisa Giraldo, Laurie Toullec, Cedric Usureau, Olivier Toutirais, Malika Smaïl‐Tabbone, Dave Lowe, Jean Luc Taupin   +10 more
wiley   +1 more source

Link Prediction on Heterophilic Graphs via Disentangled Representation Learning

, 2022
Link prediction is an important task that has wide applications in various domains. However, the majority of existing link prediction approaches assume the given graph follows homophily assumption, and designs similarity-based heuristics or ...
Aggarwal, Charu, Guo, Zhimeng, Wang, Suhang, Zhang, Xiang, Zhou, Shijie   +4 more
core