Results 31 to 40 of about 3,384 (250)

Some Isolated Cardiac Malformations Can Be Related to Laterality Defects

Journal of Cardiovascular Development and Disease, 2018
Human beings are characterized by a left–right asymmetric arrangement of their internal organs, and the heart is the first organ to break symmetry in the developing embryo.
Paolo Versacci, Flaminia Pugnaloni, Maria Cristina Digilio, Carolina Putotto, Marta Unolt, Giulio Calcagni, Anwar Baban, Bruno Marino   +7 more
doaj   +1 more source

A novel NODAL variant in a young embolic stroke patient with visceral heterotaxy

BMC Neurology
Background Ischemic stroke in young adults can be caused by a variety of etiologies including the monogenic disorders. Visceral heterotaxy is a condition caused by abnormal left–right determinations during embryonic development. We aimed to determine the
Kei Kaburagi, Yuta Hagiwara, Keiji Tachikawa, Noriko Miyake, Hisanao Akiyama, Yosuke Kawai, Yosuke Omae, Katsushi Tokunaga, Yoshihisa Yamano, Takahiro Shimizu, Satomi Mitsuhashi   +10 more
doaj   +1 more source

Locally invasive cholangiocarcinoma causing gastric outlet obstruction in heterotaxy syndrome: A case report and review of literature

Radiology Case Reports
Heterotaxy syndrome is a disease of embryo development resulting in abnormal distribution of thoracic and abdominal organs across the left-right axis.
Wanyang Qian, MD, Benjamin M. Mac Curtain, BEng, MB, BCh, BAO, James P. Ryan, MB, BCh, BAO, MCH, Suresh Navadgi, MBBS, FRACS   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Heterotaxy Syndrome and Spectrum of Cardiac Involvement

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging
Heterotaxy syndrome, a birth defect characterized by abnormal arrangement of organs, is strongly associated with complex congenital heart disease (CHD).
Munesh Tomar, Maitri Chaudhuri
doaj   +1 more source

Establishing the Embryonic Axes: Prime Time for Teratogenic Insults

Journal of Cardiovascular Development and Disease, 2017
A long standing axiom in the field of teratology states that the teratogenic period, when most birth defects are produced, occurs during the third to eighth weeks of development post-fertilization.
Thomas W. Sadler
doaj   +1 more source

Utility of Three-Dimensional Printed Model in Biventricular Repair of Complex Congenital Cardiac Defects: Case Report and Review of Literature

Children, 2022
Heterotaxy is a rare syndrome associated with cardiac complexity, anatomic variability and high morbidity and mortality. It is often challenging to visualize and provide an accurate diagnosis of the cardiac anatomy prior to surgery with the use of ...
Lauren Gabriel Betancourt, Si Hui Wong, Harinder R. Singh, Daniel Nento, Arpit Agarwal   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Situs ambiguous anomaly during laparoscopic cholecystectomy in an adult female

Nigerian Journal of Surgery, 2020
Situs anomalies are rare structural defects affecting 0.01% of general population. They present with multisystem structural defects mostly involving cardiovascular, respiratory and GI systems.
Brij Mohan Joshi, Sumitoj Singh, Ashok Kumar, Mandeep Singh Sandhu, Deepak Rana   +4 more
doaj   +1 more source