Results 161 to 170 of about 2,246,280 (273)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Multi‐Frame Image Registration for Automated Ventricular Function Assessment in Single Breath‐Hold Cine MRI Using Limited Labels

Magnetic Resonance in Medicine, Volume 95, Issue 3, Page 1762-1777, March 2026.
ABSTRACT Purpose This study aims to develop an automated framework for operator‐independent assessment of cardiac ventricular function from highly accelerated images. Methods We introduce a deep learning framework that generates reliable ventricular volumetric parameters and strain measures from fully sampled and retrospectively accelerated MR images ...
Aya Ghoul, Paxstan Cassal Paulson, Andreas Lingg, Patrick Krumm, Kerstin Hammernik, Daniel Rueckert, Sergios Gatidis, Thomas Küstner   +7 more
wiley   +1 more source

Evaluating the Genetic Overlap Between Congenital Heart Disease and Neuroblastoma Risk

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Children with congenital heart disease (CHD) have elevated neuroblastoma (NB) risk, potentially due to shared neural crest origins. We analyzed rare exonic de novo single‐nucleotide variants in 702 CHD and 454 NB trios from the Neuroblastoma Epidemiology in North America Study, Gabriella Miller Kids First Program, and a published cohort. Seven
Ji Yun Tark, Alexander Renwick, Yao Yu, Aniko Sabo, Andrew F. Olshan, Sharon E. Plon, Chad D. Huff, Philip J. Lupo   +7 more
wiley   +1 more source

Maternal Myo‐Inositol Intake and Congenital Heart Defects in Offspring: A Population‐Based Case–Control Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 3, Page 442-453, February 2026.
ABSTRACT Objective To investigate associations between maternal periconceptional (three months prior through the third pregnancy month) myo‐inositol intake and the odds of selected congenital heart defects in offspring. Design A population‐based case–control study using the National Birth Defects Prevention Study (NBDPS) database. Setting United States.
Ruiqi Cen, L. Joseph Su, Jun Ying, Mohammed S. Orloff, Elijah H. Bolin, Xiangyang Lou, Lynn M. Almli, Lorenzo D. Botto, Marilyn L. Browne, Richard H. Finnell, Mary M. Jenkins, Eirini Nestoridi, Andrew F. Olshan, Paul A. Romitti, Gary M. Shaw, Wendy N. Nembhard, the National Birth Defects Prevention Study   +16 more
wiley   +1 more source

Heterotaxy syndrome with mixed bronchopulmonary malinosculation: an unusual case report [PDF]

, 2022
Vidushi Gupta, Kalpana Bansal, Pranav Gupta, Nitin Agarwal, Saumya Pandey, Poonam Narang, Ram Krishan   +6 more
openalex   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes

Andrology, Volume 14, Issue 2, Page 528-544, February 2026.
ABSTRACT Background Epidemiological studies have reported an association between advanced paternal age at conception and an increased risk of neurodevelopmental disorders in offspring, such as autism spectrum disorder. Evidence suggests that DNA methylation alterations in spermatozoa of older men may be transmitted to the feto‐placental unit and ...
Julia Barnwell, Sophia Rahimi, Sherri Lee Jones, Donovan Chan, Josée Martel, Sara Abdessamie, Catherine M. Herba, Jean R. Séguin, William D. Fraser, Celia M. T. Greenwood, Tuong‐Vi Nguyen, Tina C. Montreuil, Jacquetta Trasler   +12 more
wiley   +1 more source

Mixed Gonadal Dysgenesis: A Comprehensive Review of Clinical Spectrum, Diagnostic Strategies, and Management Approaches

Clinical Endocrinology, Volume 104, Issue 2, Page 92-102, February 2026.
ABSTRACT Background Mixed gonadal dysgenesis (MGD) is a rare form of differences in sex development (DSD) typically associated with 45,X/46,XY mosaicism. The phenotypic presentation of MGD varies from atypical genitalia to typical male or female appearances often associated with Turner stigmata.
Dinesh Giri, Sushil Yewale, Hannah Hickingbotham, Cara Williams, Mohamed Shalaby, Julie Alderson, Julie Park   +6 more
wiley   +1 more source

Grit in the Workplace Experienced by Taiwanese Adults With Congenital Heart Disease: A Phenomenological Study

Journal of Clinical Nursing, Volume 35, Issue 2, Page 866-878, February 2026.
ABSTRACT Aim To explore how adults with congenital heart disease (ACHD) experience and express grit in the workplace. Design Qualitative study using Husserl's descriptive phenomenology. Methods Between March 2022 and June 2023, semi‐structured interviews were administered to 18 ACHD recruited from two medical centre outpatient departments.
Yu‐Shiu Liu, Chun‐Wei Lu, Hung‐Tao Chung, Jou‐Kou Wang, Ying‐Mei Shu, Chi‐Wen Chen   +5 more
wiley   +1 more source

Back to Basics: A Curriculum to Address the Pediatric Cardiac Anesthesia Workforce Crisis

Pediatric Anesthesia, Volume 36, Issue 2, Page 122-127, February 2026.
ABSTRACT The field of pediatric cardiac anesthesia faces a critical workforce shortage. Survival of children with congenital heart disease (CHD) has improved dramatically, increasing both lifetime procedural demand and case complexity. At the same time, the supply of fellowship‐trained pediatric cardiac anesthesiologists is shrinking due to an aging ...
Lindsey Loveland, Susan C. Nicolson
wiley   +1 more source