Results 131 to 140 of about 78,400 (304)

Conflict between heterozygote advantage and hybrid incompatibility in haplodiploids (and sex chromosomes)

, 2017
In many diploid species the sex chromosomes play a special role in mediating reproductive isolation. In haplodiploids, where females are diploid and males haploid, the whole genome behaves similarly to the X/Z chromosomes of diploids.
Alexandre Blanckaert, Roger K. Butlin, Ana-Hermina Ghenu, Jonna Kulmuni, Claudia Bank   +4 more
core   +1 more source

Genomic Assessment of Reintroduced African Wild Dogs Informs Conservation Translocations

Animal Conservation, EarlyView.
Few reintroduction and translocation programs incorporate genomic assessments into management planning, despite ongoing debate over how founder individuals should be selected. Here, we assess the genomic composition of reintroduced African wild dog (Lycaon pictus) populations in private reserves in South Africa, comparing them with a free‐roaming ...
Michou Weimar, Cole du Plessis, Rosemary Groom, Bettine Jansen van Vuuren, Laura Tensen   +4 more
wiley   +1 more source

Funnel plot of heterozygote comparison (GA vs. AA) in all 10 eligible studies, Begg's test p = 0.049.

, 2013
Funnel plot of heterozygote comparison (GA vs. AA) in all 10 eligible studies, Begg's test p = 0.049.
Qingyong Chen (434461), Chang Liang (434459), Xiankai Li (434460), Wan Wang (354665), Yadong Wu (434462), Mantang Qiu (434463), Yawei Xu (126970), Weiming Li (126966)   +7 more
core   +1 more source

Impact of FSHB and FSHR Genes Polymorphisms on Hormonal Profile and Sperm Retrieval Outcome in Men With Klinefelter Syndrome: A Clinical–Genetic Predictive Study

Andrology, EarlyView.
ABSTRACT Background Genetic variability within the follicle‐stimulating hormone (FSH)‐related genes might contribute to phenotypic heterogeneity in patients with Klinefelter syndrome (KS), yet its clinical impact on sperm retrieval remains unclear. Objectives To investigate the association between FSHB c.211 G > T and FSHR polymorphisms (c.2039 A > G ...
Andrea Graziani, Giuseppe Grande, Maria Santa Rocca, Massimo Iafrate, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +6 more
wiley   +1 more source

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients

Clinical Genetics, EarlyView.
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Camille Bergès, Clément Sauvestre, Sophie Naudion, Catherine Vincent Delorme, Thomas Smol, Mélanie Rama, Stephanie Moortgat, Isabelle Maystadt, Rogier Kersseboom, Martina Wilke, Stefan Barakat, Yoann Vial, Laurence Perrin, Sandrine Passemard, Farooq Ahmad, Muhammad Umair, Tobias Haack, Mona Grimmel, Alma Kuechler, Anne Slavotinek, Patrick Devine, Ugur Hodoglugil, Faisal Zafar, Erum Afzal, Tracy Dudding‐Byth, Guillaume Jouret, Lucas Herissant, Stephanie Efthymiou, Henry Houlden, Marine Legendre, Vincent Michaud   +30 more
wiley   +1 more source

Heterozygote advantage at MHC DRB may influence response to infectious disease epizootics

, 2015
The effect of MHC polymorphism on individual fitness variation in the wild remains equivocal; however, much evidence suggests that heterozygote advantage is a major determinant.
Gemmell, Neil J., Negro, Sandra S., Pearson, John, Negro, Sandra Silvia, Osborne, Amy J., Kennedy, Martin A., Chilvers, B. Louise   +6 more
core   +1 more source

Conservation implications of low contemporary connectivity along the Mid‐Atlantic Ridge in hydrothermal vent gastropods

Conservation Biology, EarlyView.
Abstract Polymetallic sulfide deposits produced at hydrothermal vent fields are targets for mining exploitation along the Mid‐Atlantic Ridge, threatening the functioning and resilience of vent ecosystems that provide multiple ecosystem services. Knowledge about connectivity between vents will inform conservation practices.
E. Portanier, A. Tran Lu Y, F. Pradillon, C. Daguin‐Thiébaut, S. Ruault, P. Collins, E. Omnes, S. Fuchs, J. Carlsson, D. Jollivet, M. Matabos   +10 more
wiley   +1 more source

Estimating the effective number of breeders from heterozygote excess in progeny

, 1999
International audienceThe heterozygote-excess method is a recently published method for estimating the effective population size (N-e). It is based on the following principle: When the effective number of breeders (N-eb) in a population is small, the ...
Luikart, G., Cornuet, J. M.
core  

Related Article from Translating Cyclooxygenase Signaling in Patch Heterozygote Mice into a Randomized Clinical Trial in Basal Cell Carcinoma

, 2010
Related Article from Translating Cyclooxygenase Signaling in Patch Heterozygote Mice into a Randomized Clinical Trial in Basal Cell ...
Jack L. Arbiser (527306)
core   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, EarlyView.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source