Results 71 to 80 of about 81,851 (305)

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Heterozygote/homozygote concordance scatterplot of scaled z−statistics, .

, 2022
Each point corresponds to the of the heterozygote and homozygote KO lines of a particular gene. Counts (%) for each significance combination are superimposed; while the axes extend to [−3, 3], the counts apply to all data, including those beyond the ...
Habib Ganjgahi (4470775), Chris Holmes (7580), Hugh Morgan (598414), George Nicholson (106301), Steve D. M. Brown (8293281), Ann-Marie Mallon (1196)   +5 more
core   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

Detection and characterization of the heterozygote state for lipoprotein lipase deficiency.

, 1989
Because there are no characteristic clinical or biochemical manifestations, the heterozygote state for lipoprotein lipase (LPL) deficiency has been difficult to detect. Measurements of postheparin plasma LPL activity and of LPL mass were performed in six
J D Brunzell, P H Iverius, W Y Fujimoto, S P Babirak   +3 more
core   +1 more source

HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation [PDF]

, 2020
Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 ...
Carrington, M., Arora, Jatin, Pierini, F., McLaren, Paul J., Arora, J., Fellay, Jacques, McLaren, P.J., Arora, J. ; https://orcid.org/, Pierini, F. ; https://orcid.org/, Lenz, T.L., Lenz, T. ; https://orcid.org/, Carrington, Mary, McLaren, P., Fellay, J., Pierini, Federica, Lenz, Tobias L.   +15 more
core   +2 more sources

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Differential expression of vasopressin alleles in the Brattleboro heterozygote

, 1988
A solution hybridization/RNase protection assay for the molar quantitation of vasopressin and oxytocin mRNAs, using synthetic complementary RNA probes, is described.
TG Sherman, SJ Watson
core   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Clinical comparison of hearing-impaired patients with DFNB1 against heterozygote carriers of connexin 26 mutations

, 2011
The aim of the study is to assess clinical characteristics of individuals with nonsyndromic sensorineural hearing loss (NSSNHL) with genetic mutations in GJB2 and/or GJB6.
Lipan, Michael, Angeli, Simon, Xiaomei Ouyang, Xue-Zhong Liu, Liu, Xue-Zhong, Michael Lipan, Denise Yan, Ouyang, Xiaomei, Yan, Denise, Du, Li Lin, Simon Angeli, Li Lin Du   +11 more
core   +1 more source

The clinical different features about spontaneous preterm labor between women who have AA homozygote and AG heterozygote of rs2485579.

, 2023
The clinical different features about spontaneous preterm labor between women who have AA homozygote and AG heterozygote of rs2485579.
Jae Young Yoo (6792722), Young Ah You (17480271), Young Min Hur (13186362), Soo Min Kim (1580188), Gain Lee (17480274), Sunwha Park (13186356), Young Ju Kim (671847)   +6 more
core   +1 more source