Results 71 to 80 of about 78,400 (304)

Levels of multiallelic overdominance fitness, heterozygote excess and heterozygote deficiency

Theoretical Population Biology, 1990
Concepts and results on selection balance in multiallelic systems are described. These include a multidimensional concept of heterozygote excess and heterozygote deficiency, a hierarchy of means of assessment of heterozygote advantage, comparisons and contrasts of allelic versus gametic polymorphic states, and conditions defining stable equilibria of ...
openaire   +3 more sources

Differential expression of vasopressin alleles in the Brattleboro heterozygote

, 1988
A solution hybridization/RNase protection assay for the molar quantitation of vasopressin and oxytocin mRNAs, using synthetic complementary RNA probes, is described.
TG Sherman, SJ Watson
core   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Clinical comparison of hearing-impaired patients with DFNB1 against heterozygote carriers of connexin 26 mutations

, 2011
The aim of the study is to assess clinical characteristics of individuals with nonsyndromic sensorineural hearing loss (NSSNHL) with genetic mutations in GJB2 and/or GJB6.
Lipan, Michael, Angeli, Simon, Xiaomei Ouyang, Xue-Zhong Liu, Liu, Xue-Zhong, Michael Lipan, Denise Yan, Ouyang, Xiaomei, Yan, Denise, Du, Li Lin, Simon Angeli, Li Lin Du   +11 more
core   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

ORs with 95%CIs for heterozygote and homozygote genotypes of each SNP.

, 2014
ORs with 95%CIs for heterozygote and homozygote genotypes of each SNP.
Xiaoyan Ge (263227), Kai Cui (239147), Honglin Ma (602505)   +2 more
core   +1 more source

The clinical different features about spontaneous preterm labor between women who have AA homozygote and AG heterozygote of rs2485579.

, 2023
The clinical different features about spontaneous preterm labor between women who have AA homozygote and AG heterozygote of rs2485579.
Jae Young Yoo (6792722), Young Ah You (17480271), Young Min Hur (13186362), Soo Min Kim (1580188), Gain Lee (17480274), Sunwha Park (13186356), Young Ju Kim (671847)   +6 more
core   +1 more source

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Maximum likelihood estimates of female drive heterozygote fitness.

Maximum likelihood estimates of female drive heterozygote fitness.
Xuejiao Xu (1532944), Xuyang Ni (18320231), Shimin Chen (5368544), Suhan Ma (18320228), Weizhe Chen (5920778), Xiaomu Qiao (656142), Jackson Champer (4261381), Jia Huang (42138)   +7 more
core   +1 more source