Results 81 to 90 of about 81,851 (305)

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Funnel plot of heterozygote comparison (1772 C/T, T allele vs. C allele).

, 2013
Funnel plot of heterozygote comparison (1772 C/T, T allele vs. C allele).
Chi Zhang (9857), Jian-Xin Ma (486456), Qu Zhang (486455), Hong-Yan Cheng (407777), Li-Ping Xu (486453), Hong-Cheng Zhu (486452), Xin-Chen Sun (486457), Jia Liu (41593), Jing Cai (112307), Lian-Jun Zhao (486454), Qin Qin (83769), Xi Yang (112884)   +11 more
core   +1 more source

Carrier frequency of autosomal recessive monogenic disorders in the peruvian population

Frontiers in Genetics
ObjectiveAutosomal recessive diseases represent an important group of genetic disorders whose frequency may be reduced through population screening strategies or premarital diagnosis, particularly in low- and middle-income countries, where some of these ...
Hugo Hernán Abarca Barriga, Hugo Hernán Abarca Barriga, Flor Del Milagro Vásquez-Sotomayor, Flor Del Milagro Vásquez-Sotomayor, Renzo Punil Luciano, Renzo Punil Luciano   +5 more
doaj   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Maximum likelihood estimates of female drive heterozygote fitness.

Maximum likelihood estimates of female drive heterozygote fitness.
Xuejiao Xu (1532944), Xuyang Ni (18320231), Shimin Chen (5368544), Suhan Ma (18320228), Weizhe Chen (5920778), Xiaomu Qiao (656142), Jackson Champer (4261381), Jia Huang (42138)   +7 more
core   +1 more source

Forest plot of heterozygote comparison for overall comparison (CA vs. CC).

, 2013
Forest plot of heterozygote comparison for overall comparison (CA vs. CC).
Liang Wang (23021), Ming Wang (172316), Xiao-Yang Zhu (468567), Yu Lin (370243)   +3 more
core   +1 more source

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Bailey M. Tibben, Maud Maillard, Victoria M. Pratt, Ann M. Moyer, Debbie M. Figueroa, Michelle Whirl‐Carrillo, Andrea Gaedigk, Gabriele Stocco, Matthias Schwab, Kelly E. Caudle, Jun J. Yang   +10 more
wiley   +1 more source

ORs with 95%CIs for heterozygote and homozygote genotypes of each SNP.

, 2014
ORs with 95%CIs for heterozygote and homozygote genotypes of each SNP.
Xiaoyan Ge (263227), Kai Cui (239147), Honglin Ma (602505)   +2 more
core   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Funnel plot of heterozygote comparison (1790 G/A, A allele vs. G allele).

, 2013
Funnel plot of heterozygote comparison (1790 G/A, A allele vs. G allele).
Chi Zhang (9857), Jian-Xin Ma (486456), Qu Zhang (486455), Hong-Yan Cheng (407777), Li-Ping Xu (486453), Hong-Cheng Zhu (486452), Xin-Chen Sun (486457), Jia Liu (41593), Jing Cai (112307), Lian-Jun Zhao (486454), Qin Qin (83769), Xi Yang (112884)   +11 more
core   +1 more source