Results 151 to 160 of about 131,872 (335)

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

open access: yesAdvanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare   +7 more
wiley   +1 more source

Formation of Methane by Catalytic Hydrogenolysis on n-Hexane

open access: bronze, 1967
Yoshiro Morita   +2 more
openalex   +2 more sources

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

open access: yesAdvanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai   +12 more
wiley   +1 more source

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

open access: yesAdvanced Science, EarlyView.
This study demonstrates that the atypical dehydrogenase/isomerase FabX in Type‐II fatty acid biosynthesis pathway is essential for H. pylori infection by retaining unsaturated fatty acid synthesis and producing superoxide (ROS). A small molecule FBX‐1991 that specifically targets FabX to inhibit H.
Lin Zhang   +9 more
wiley   +1 more source

Thermally Reconstructed Ru/La‐Co3O4 Nanosheets with Super Thermal Stability for Catalytic Combustion of Light Hydrocarbons: Induced Surface LaRuO3 Active Phase

open access: yesAdvanced Science, EarlyView.
The high‐temperature induced the exsolution of La from La‐Co3O4 lattice and facilitated the in situ formation of highly active LaRuO3 perovskite through a solid‐phase reaction with surface RuOx. This process significantly enhanced the thermal and hydrothermal stability of Ru/La‐Co3O4 for light hydrocarbons (LHs) oxidation, providing an innovative ...
Biao Gao   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy