Results 81 to 90 of about 1,606 (180)
Integrating Affinity Chromatography in the Platform Process for Adenovirus Purification
Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1780-1792, July 2025.Peptide‐functionalized affinity resins with high adenovirus binding capacity, recovery, and contaminant removal afford excellent productivity, and reduced impurities in a three‐step purification process. ABSTRACT Adenoviral vectors (AdVs) are gaining prominence in cancer therapy and vaccine development, posing the need for a modern AdV manufacturing ...
Yuxuan Wu +7 more
wiley +1 more source
Hexon modification and vectors used in this study.
, 2015 (A) Modification of HVR5 of Ad5 hexon. Amino acids 269 to 281 of HVR5 were replaced by a synthetic CKS17 peptide, which contains the TGFβ active site motif (bold letters) and is flanked by two different short linker sequences (bold italic letters).
Stefan Kochanek (305343) +6 more
core +1 more source
Journal of Medical Virology, Volume 97, Issue 7, July 2025.ABSTRACT Human adenoviruses of species B (HAdV‐B) can cause upper respiratory tract infections and conjunctivitis, but also severe lower respiratory tract infections (LRTI). Although HAdV‐associated LRTI are non‐notifiable in Germany, typing data of our Adenovirus Reference Laboratory indicated an HAdV‐B3 epidemic in 2023, with 67 samples initially ...
Tina Ganzenmueller +5 more
wiley +1 more source
Cancer Science, Volume 116, Issue 7, Page 1897-1907, July 2025.CDX2 promoter‐controlled oncolytic adenovirus attenuates CDX2‐positive colorectal cancer liver metastasis growth in a mouse model. ABSTRACT Colorectal cancer (CRC) is the second leading cause of cancer death worldwide, and liver metastasis (CRLM) is the most common among its distant metastases.
Naohiko Nakamura +4 more
wiley +1 more source
, 2007 Adenovirus is a significant pathogen in immunocompromised patients and is widely utilized as a gene delivery vector, so a detailed understanding of the human immune response to adenovirus infection is critical.
Mautner, Vivien +5 more
core +1 more source
, 2023 List of reference Human Adenovirus strains used in the manuscript’s hexon gene phylogenetic comparisons.
Lan Tuyet Phung (17350704) +19 more
core +1 more source
Phosphorylation State of RB Modulates Ferroptotic Sensitivity
Cell Biochemistry and Function, Volume 43, Issue 6, June 2025.ABSTRACT Tumor suppressor RB is a central regulator of cell cycle progression. By binding to E2F transcription factors, RB can inhibit transcription of E2F target genes to cause cell cycle arrest. Cyclin dependent kinases (CDK) regulate the interaction of RB/E2F by phosphorylating RB at multiple sites.
Nishanth Kuganesan +3 more
wiley +1 more source
SP70 epitope was incorporated in hexon hypervariable regions 1, 2, or 7.
, 2013 (A) Rescued viruses were amplified, and viral DNA was analyzed to confirm stable modification of hexon genes. Hexon-specific PCR primers HexU and SP70r, Hu1 and Hr1 confirmed incorporation of coding regions for SP70 epitope inserts at the hexon HVR1 ...
Xiaobo Su (313576) +7 more
core +1 more source
, 1909 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Petrie, J M +1 more
openaire +2 more sources
Development of Methods to Produce SARS CoV‐2 Virus‐Like Particles at Scale
Biotechnology and Bioengineering, Volume 122, Issue 5, Page 1118-1129, May 2025.ABSTRACT The devastating global toll precipitated by the SARS CoV‐2 outbreak and the profound impact of vaccines in stemming that outbreak has established the need for molecular platforms capable of rapidly delivering effective, safe and accessible medical interventions in pandemic preparedness.
Melissa A. Edeling +12 more
wiley +1 more source