Results 71 to 80 of about 1,606 (180)

In Situ Sustained Delivery of Tumor Cell‐Derived Extracellular Nanovesicles With Oncolytic Adenoviruses for Potentiating Cancer Immunotherapy

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
ABSTRACT Oncolytic adenoviruses (OVs) can directly eliminate cancer cells and subsequently activate immune responses, exhibiting potent antitumor therapeutics. However, it was observed that the immune cells can also be lysed during viral treatment, evidently dampening the OVs‐mediated antitumor immune response.
Tianye Wang, Sheng Zhao, Zao Ji, Zhonggui He, Zhenguo Cheng, Zhen Gu, Yuqi Zhang, Jin Sun, Funan Liu, Mengchi Sun   +9 more
wiley   +1 more source

EXPERIMENTAL LIVER NECROSIS; I. THE HEXON BASES [PDF]

Journal of Experimental Medicine, 1907
1. The liver of the dog in which necrosis has been produced by injection of hæmatoxic immune sera is characterized in the less marked forms by a storing up of nitrogen in the persisting living cells, while in the diffuse forms the total nitrogen content is but slightly above the normal. This last is to be explained by the great diminution in persisting
H C, Jackson, R M, Pearce
openaire   +2 more sources

Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors [PDF]

Scientific Reports, 2016
AbstractThe immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus serotypes. However, chimeric
Jingyi Yan, Jianing Dong, Jiaxin Wu, Rui Zhu, Zhen Wang, Baoming Wang, Lizheng Wang, Zixuan Wang, Haihong Zhang, Hui Wu, Bin Yu, Wei Kong, Xianghui Yu   +12 more
openaire   +2 more sources

Treatment of Severe Adenovirus Infection With HAdV‐B21 in a Young Obese Male With Normal Immunity

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Adenovirus infections are usually mild, but rare serotypes like “HAdV‐B21” can cause severe pneumonia even in healthy individuals. We report a 32‐year‐old immunocompetent obese male who developed life‐threatening HAdV‐B21 pneumonia (PaO2/FiO2 62 mmHg), requiring mechanical ventilation.
Ji Peng, Zhen Wang, Shili Zhong
wiley   +1 more source

Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies

Virology Journal, 2017
Background Adenoviruses are common pathogens infecting animals and humans. They are classified based on serology, or genome sequence information. These methods have limitations due to lengthy procedures or lack of infectivity data.
Martin Pacesa, Rodinde Hendrickx, Manuela Bieri, Justin W. Flatt, Urs F. Greber, Silvio Hemmi   +5 more
doaj   +1 more source

Anti‐PF4 disorders: Pathogenesis, diagnosis and treatment

British Journal of Haematology, Volume 207, Issue 3, Page 709-722, September 2025.
Anti‐platelet factor 4 (PF4) disorders include heparin‐induced thrombocytopenia (HIT) and vaccine‐induced immune thrombocytopenia and thrombosis (VITT)/VITT‐like disorders. The formation of immunoglobulin G (IgG)/PF4 immune complexes facilitates uncontrolled activation of platelets, neutrophils and monocytes via IgG‐mediated Fcγ receptor binding.
Megan V. Preece, Devi V. Pathak, Mike Laffan, Deepa J. Arachchillage   +3 more
wiley   +1 more source

Structural assessment of thirteen hexon proteins by Procheck.

, 2013
Structural assessment of thirteen hexon proteins by Procheck.
Jing-Fei Wang (329664), Jing-Jun Liu (179443), Xiao-Hui Yuan (179418), Wen-Jing Jin (179386), Cai-Feng Chen (179390), Jian Yang (12136), Bin-Bin Zhao (179424), Ying-Chen Wang (329660), Ding Zhang (179432), Lu-Lu Gong (179409), Ying-Ying Guo (329666), You-Wen He (179462)   +11 more
core   +1 more source

Comparison of human memory CD8 T cell responses to adenoviral early and late proteins in peripheral blood and lymphoid tissue. [PDF]

PLoS ONE, 2011
Treatment of invasive adenovirus (Ad) disease in hematopoietic stem cell transplant (SCT) recipients with capsid protein hexon-specific donor T cells is under investigation.
Amita Joshi, Biwei Zhao, Cara Romanowski, David Rosen, Phyllis Flomenberg   +4 more
doaj   +1 more source

Development of a Rapid Isothermal Assay for Detection of Adenovirus Types Important in Respiratory Infections

Influenza and Other Respiratory Viruses, Volume 19, Issue 8, August 2025.
ABSTRACT Background Nucleic acid amplification tests (NAATs) for human adenoviruses (HAdVs) causing respiratory infections usually target the hexon gene. However, new HAdV types with substantial variations in the hexon gene may not be detected. Thus, we focus on NAATs based on a conserved region in the penton gene to detect all HAdV types causing ...
Benedikt Beilstein, Iris Bachmann, Martin Spiegel, Frank T. Hufert, Gregory Dame   +4 more
wiley   +1 more source

Adenovirus serotype 5 hexon mediates liver gene transfer

, 2008
Adenoviruses are used extensively as gene transfer agents, both experimentally and clinically. However, targeting of liver cells by adenoviruses compromises their potential efficacy.
Morita, T, Greig, JA, Napoli, C., BAKER A., Buckley, Suzanne M.K., Morita, Takashi, van Rooijen, N, Hlavenga, MJE, Monteiro, Robson Q., van Rooijen, Nico, PARKER A., ATODA H., Bhella, D, Napoli, Claudio, Napoli, C, Barker, Kristeen, Denby, Laura, MORITA T., Francischetti, I.M., Atoda, H., Morita, T., MCVEY J., Nicklin, SA, Barouch, D.H., BARKER K., Denby, L, MONTEIRO R., Buckley, SMK, Buckley, S.M.K., Monteiro, R.Q., Parker, Alan L., Havenga, Menzo J. L., BHELLA D., Atoda, H, Waddington, Simon N., Bhella, David, Custers, J, Parker, A., Barker, K., Custers, Jerome, Waddington, S.N., Denby, L., WADDINGTON S., Francischetti, Ivo M.B., Baker, Andrew H., Baker, A.H., CUSTERS J., Nicklin, S.A., McVey, John H., BUCKLEY S., HAVENGA M., Monteiro, RQ, DENBY L., VAN ROOIJEN N., Parker, AL, Francischetti, IMB, McVey, J.H., Francischetti, I.M.B., Havenga, Menzo J.E., Bhella, D., Nicklin, Stuart A., van Rooijen, N., Buckley, Suzanne M. K., Baker, AH, Custers, J., Waddington, SN, BAROUCH D., Pink, R, Parker, A.L., van Rooijen, R.N., McVey, JH, Pink, R., Havenga, M.J., Greig, J.A., Barker, K, Havenga, M.J.E., Barouch, Dan H., FRANCISCHETTI I., Francischetti, Ivo M. B., Atoda, Hideko, Barouch, DH, Greig, J., NICKLIN S., Waddington, S., Buckley, S.M., PINK R., Pink, Rebecca, GREIG J., Greig, Jenny A.   +88 more
core   +1 more source