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Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter

Biochemical Pharmacology, 2004
Glucose metabolism is essential for survival of bloodstream form Trypanosoma brucei subspecies which cause human African trypanosomiasis (sleeping sickness). Hexose analogues may represent good compounds to inhibit glucose metabolism in these cells. Delivery of such compounds to the parasite is a major consideration in drug development.
Laurent, Azema   +11 more
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Sodium-hexose interactions

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1971
Hexose and sodium can interact in the columnar epithelial cells of the intestine at various levels ( a ) in changing availability of energy, ( b ) at transport sites, ( c ) at the coupling mechanism between metabolism and transport or the coupling between Na transport ...
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Estimation of hexose diphosphate

Archives of Biochemistry and Biophysics, 1954
Abstract A new method based on the anthrone reaction is proposed for the quantitative determination of hexose diphosphate in order to eliminate the uncertain fructose equivalent. The method can he used for determination of hexose diphosphate of 5–400 μg. with an experimental error for a duplicate determination of 2.4%.
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Different Tastes of Enantiomorphic Hexoses

Science, 1962
Studies of synthetic iron sulfides formed from aqueous solution at 25 degrees C and atmospheric pressure have revealed the existence of a new phase, tetragonal FeS. This phase is formed as the initial corrosion product of metallic iron or steel in solutions of hydrogen sulfide. It has been discovered as an iron corrosion product in the sediments of the
W C, BOYD, S, MATSUBARA
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Hexose nucleic acids

Pure and Applied Chemistry, 1993
Abstract
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Total Synthesis of the L-Hexoses

Science, 1983
Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.
S Y, Ko   +5 more
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Hexose-Monophosphate Oxidation

1969
Publisher Summary This chapter describes the hexose-monophosphate oxidation pathway ribose 5-phosphate, which is the most important structural material generated during the operation of the cycle, as it is one of the building blocks for nucleic acid synthesis, in all organisms.
SANDRO PONTREMOLI, ENRICO GRAZI
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Improved Intestinal Membrane Permeability of Hexose-Quinoline Derivatives via the Hexose Transporter, SGLT1

Journal of Pharmaceutical Sciences, 2008
Intestinal membrane permeability is an important factor affecting the bioavailability of drugs. As a strategy to improve membrane permeability, membrane transporters are useful targets since essential nutrients are absorbed efficiently via specific transporters.
Katsumasa, Otake   +7 more
openaire   +2 more sources

Hexose metabolism in pancreatic islets: Enzyme-to-enzyme tunnelling of hexose 6-phosphates

International Journal of Biochemistry, 1991
The fate of unlabelled D-glucose and D-[2-3H]glucose in pancreatic islets was simulated taking into account experimental values for glycolytic flux, intracellular concentration of D-glucose 6-phosphate and phosphoglucoisomerase activity. The model, which also takes into account the isotopic discrimination in velocity and intramolecular transfer of ...
Malaisse, Willy, Bodur, Hakan
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