Results 81 to 90 of about 7,072 (218)

Group sequential designs for negative binomial outcomes

, 2018
Count data and recurrent events in clinical trials, such as the number of lesions in magnetic resonance imaging in multiple sclerosis, the number of relapses in multiple sclerosis, the number of hospitalizations in heart failure, and the number of ...
Friede, Tim, Glimm, Ekkehard, Mütze, Tobias, Schmidli, Heinz   +3 more
core   +1 more source

Cardiac surveillance in immune checkpoint inhibitor therapy: Insights from the Essen Cardio‐oncology Registry

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia, Lisa Zimmer, Lena Lampe, Dimitra Vlachopoulou, Matthias Totzeck, Tienush Rassaf, Raluca I. Mincu   +6 more
wiley   +1 more source

Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction

ESC Heart Failure, 2022
Aims Evidence on the association between ambient temperature and the onset of acute heart failure (AHF) is scarce and mixed. We sought to investigate the incidence of AHF admissions based on ambient temperature change, with particular interest in ...
Takahiro Jimba, Shun Kohsaka, Masao Yamasaki, Toshiaki Otsuka, Kazumasa Harada, Yasuyuki Shiraishi, Shinji Koba, Makoto Takei, Takashi Kohno, Kenichi Matsushita, Tetsuro Miyazaki, Satoshi Kodera, Shigeto Tsukamoto, Kiyoshi Iida, Akito Shindo, Daisuke Kitano, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama, Tokyo CCU Network Scientific Committee   +19 more
doaj   +1 more source

Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular‐Kidney‐Metabolic Syndrome

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular‐kidney‐metabolic (CKM) syndrome is defined by the pathologic interconnections between obesity, diabetes, chronic kidney disease and cardiovascular disease. An important and underrecognized pathophysiologic factor underlying CKM syndrome is obesity‐induced aldosterone excess.
Evan Zeitler, Klara R. Klein, Ildiko Lingvay, Anthony Pick, Liana K. Billings   +4 more
wiley   +1 more source

Mortality and Morbidity in HFrEF, HFmrEF, and HFpEF Patients with Diabetes in the Middle East

Oman Medical Journal, 2020
We sought to estimate the mortality and morbidity in diabetic acute heart failure (AHF) patients stratified by left ventricular ejection fraction.We analyzed the data of patients with AHF from seven Middle Eastern countries (Bahrain, Oman, Yemen, Kuwait, UAE, Qatar, and Saudi Arabia) from February to November 2012, who were enrolled in a multinational ...
Mohammed Al-Jarallah, Rajesh Rajan, Ibrahim Al-Zakwani, Raja Dashti, Bassam Bulbanat, Mustafa Ridha, Kadhim Sulaiman, Alawi A. Alsheikh-Ali, Prashanth Panduranga, Khalid F. AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Nooshin Bazargani, Nidal Asaad, Haitham Amin   +17 more
openaire   +3 more sources

NT‐proBNP as a Predictor of Atrial Fibrillation Recurrence After Cryoballoon, Radiofrequency and Pulsed‐Field Ablation

Pacing and Clinical Electrophysiology, EarlyView.
Central Illustration: In a study investigating AF recurrence after PVI with RFA, CBA, and PFA, elevated NT‐proBNP emerged as a strong predictor of recurrence within the first year, outperforming other clinical measures. Color‐coded recurrence‐free survival probability charts derived from these data are proposed to support individualized clinical ...
Johannes Bruss, Thomas Kueffer, Hildegard Tanner, Fabian Noti, Andreas Haeberlin, Gregor Thalmann, Nikola Asenov Kozhuharov, Boldizsar Kovacs, Valon Spahiu, Claudia Herrera Siklody, Tobias Reichlin, Laurent Roten   +11 more
wiley   +1 more source

Growth differentiation factor 15 : a novel biomarker with high clinical potential

, 2019
Initially considered as a macrophage inhibitor (macrophage inhibitory cytokine-1), growth differentiation factor 15 (GDF-15) has been identified as a pleiotropic protein that plays key roles in prenatal development, in inflammation, in the regulation of ...
De Vos, Leen, Delanghe, Joris, Desmedt, Stéphanie, Desmedt, Valérie, Speeckaert, Marijn, Speeckaert, Reinhart   +5 more
core   +1 more source

Impact of left ventricular ejection fraction on clinical outcomes after left main coronary artery revascularization [PDF]

, 2020
Aim: To evaluate the impact of left ventricular ejection fraction (LVEF) on 3-year outcomes in patients with left main coronary artery disease (LMCAD) undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in the ...
Crowley, A. (Aaron), Dressler, O. (Ovidiu), Head, S.J. (Stuart), Kappetein, A.P. (Arie Pieter), Milojevic, M. (Milan), Puskas, J.D. (John), Sabik, J.F. (Joseph), Serruys, P.W.J.C. (Patrick), Stone, G.W. (Gregg), Thuijs, D.J.F.M. (Daan)   +9 more
core   +1 more source

Population Pharmacokinetics of the Novel Myeloperoxidase Inhibitor Mitiperstat

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Mitiperstat is a novel myeloperoxidase inhibitor being investigated for the treatment of heart failure, metabolic dysfunction‐associated steatohepatitis, and chronic obstructive pulmonary disease. Pharmacokinetic data from five clinical trials were used to develop a mitiperstat population pharmacokinetics (popPK) model.
Mikael Sunnåker, Jacob Leander, Hans Ericsson   +2 more
wiley   +1 more source

Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction

Singapore Medical Journal
Introduction: Data on heart failure (HF) with mildly reduced ejection fraction (HFmrEF) is still emerging, especially in Asian populations. This study aims to compare the clinical characteristics and outcomes of Asian HFmrEF patients with those of HF ...
Julian Cheong Kiat Tay, Shaw Yang Chia, Siew Hui Michelle Koh, David Kheng Leng Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Shao Guang Lee, Patrick Zhan Yun Lim, Jonathan Yap   +9 more
doaj   +1 more source