Results 131 to 140 of about 28,042 (215)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Long-term hemodynamic responses and reverse remodeling after pharmacotherapy in HFpEF versus HFrEF: a systematic review and meta-analysis [PDF]

The acute response to therapeutic afterload reduction differs between heart failure with preserved (HFpEF) versus reduced ejection fraction (HFrEF), with larger left ventricular (LV) stroke work augmentation in HFrEF compared with HFpEF.
de Man, Frances S., van Loon, Ramon B., Handoko, M. Louis, Bakermans, Adrianus J., Burchell, George L., Nassiri, Soufiane, van de Bovenkamp, Arno A.   +6 more
core  

Ventilatory Response to Exercise in HFrEF-COPD: Importance of Exercise Modality

Background: Heart failure with reduced ejection fraction (HFrEF) frequently coexists with chronic obstructive pulmonary disease (COPD), and both conditions share symptoms such as exertional dyspnea.
Marta Íscar Urrutia, Ramón Fernández Álvarez, Beatriz Díaz Molina, Marina Acebo Castro, Marta García Clemente, Julia Herrero Huertas   +5 more
core   +1 more source

Slow calcium removal contributes to impaired lusitropic response to β‐adrenergic stimulation in HFpEF mice

The Journal of Physiology, EarlyView.
Abstract figure legend Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure, yet major gaps remain in our understanding of its underlying mechanisms, disease progression and effective treatment strategies. Mice with HFpEF exhibited exercise intolerance and diastolic dysfunction in vivo, while isolated hearts ...
Tamzin Zawadzki, Diana S. Usai, Sif G. Kaad, Katrine H. Rasmussen, Mie S. Larsen, Jens C. B. Jacobsen, Morten B. Thomsen   +6 more
wiley   +1 more source

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Catheter Ablation Versus Medical Therapy in Atrial Fibrillation With Heart Failure With Reduced or Mildly Reduced Ejection Fraction: A GRADE‐Assessed Systematic Review and Meta‐Analysis

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
In patients with atrial fibrillation and HFmrEF/HFrEF, catheter ablation was associated with lower mortality and improved cardiac function compared with conventional medical therapy, while cardiovascular hospitalization was not significantly reduced. The overall certainty of evidence ranged from moderate to high.
Aleena Amir Malik, Nasir Saeed, Goodluck Oparaugo, Muhammad Waqar Shahid, Waqas Kareem, Fatima Yousaf, Zain Ul Abedeen, Fatima Sajjad, Kashif Yousaf, Fizza Kazmi, Rubab Zahra, Ishfaq Ali, Sahil Kumar, Tanzeela Gul, Zartasha Rahim, Abdul Basit, Manal Sharif, Anum Noor, Habib ur Rehman, Imdad Ullah Shah, Abdullah Afridi   +20 more
wiley   +1 more source

From VICTORIA to VICTOR: Where Vericiguat Fits in HFrEF Care [PDF]

Background. Vericiguat, an oral soluble guanylate cyclase stimulator, augments impaired NO-sGC-cGMP signaling in heart failure with reduced ejection fraction (HFrEF).
Skibicka, Katarzyna, Wesołowska, Weronika, Jaśniak, Albert, Bujak, Robert   +3 more
core  

Cardiac Resynchronization as an Enabler of ARNI Efficacy: Insights From a Real‐World Cohort

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
CRT provides the mechanical substrate that enables sacubitril/valsartan to maximize reverse remodeling. In this real‐world cohort, ARNI therapy was associated with greater improvement in left ventricular function and fewer clinically validated device‐detected HF events, particularly among CRT responders, supporting a synergistic interaction between ...
Amato Santoro, Laura Spaccaterra, Maurizio Collantoni, Claudia Baiocchi, Benedetta Maria Natali, Stefano Lunghetti, Antonio Pagliaro, Niccolò Manetti, Francesco Morrone, Massimo Fineschi, Alberto Palazzuoli   +10 more
wiley   +1 more source

A feasibility study evaluating seismocardiography for the detection of heart failure. [PDF]

PLOS Digit Health
Agam A, Korsgaard E, Yding Haugstrup T, Janus Grønn Emerek K, Weinkouff Pedersen M, Omar M, Eifer Møller J, Kragholm K, Schmidt SE, Søgaard P.   +9 more
europepmc   +1 more source