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Deutsche medizinische Wochenschrift (1946), 2021
Since publication of the European Society guidelines for the diagnosis and treatment of acute and chronic heart failure in 2016, numerous studies provided new evidence how to further optimize heart failure therapy.Besides recent device-based therapeutic options, promising new drug developments give a glimmer of hope that the prognosis of this ...
Gülmisal, Güder, Stefan, Frantz
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Since publication of the European Society guidelines for the diagnosis and treatment of acute and chronic heart failure in 2016, numerous studies provided new evidence how to further optimize heart failure therapy.Besides recent device-based therapeutic options, promising new drug developments give a glimmer of hope that the prognosis of this ...
Gülmisal, Güder, Stefan, Frantz
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HFrEF phenotyping in real life
European Heart Journal, 2023Abstract Background In May 2021 an HFA position paper[1] by Rosano GMC et al. classified patients with heart failure with reduced ejection fraction (HFrEF) into 11 phenotypes based on blood pressure, heart rate, renal function, potassium level and rhythm and assigned them to different prescription ...
A Weidenhammer +9 more
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Metabolomic Profile in HFpEF vs HFrEF Patients
Journal of Cardiac Failure, 2020Heart failure with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) are associated with metabolic derangements, which may have different pathophysiological implications.In new-onset HFpEF (EF of ≥50%, n = 46) and HFrEF (EF of
Camilla Hage +13 more
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Skeletal muscle alterations in HFrEF vs. HFpEF
Current Heart Failure Reports, 2017Severe exercise intolerance and early fatigue are hallmarks of heart failure patients either with a reduced (HFrEF) or a still preserved (HFpEF) ejection fraction. This review, therefore, will provide a contemporary summary of the alterations currently known to occur in the skeletal muscles of both HFrEF and HFpEF, and provide some further directions ...
Volker, Adams +2 more
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HFrEF pharmacological treatment: ivabradine
2018Ivabradine slows down the heart rate through a blockade of the funny current channels in the sinoatrial node cells. The efficacy of the drug was tested in a large outcome clinical trial in stable chronic heart failure with reduced ejection fraction, in sinus rhythm, on a contemporary background therapy including beta blockers.
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Neue Therapiekonzepte der HfrEF
Kardiologie up2date, 2021Amr Abdin, Jan Wintrich, Michael Böhm
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Co-morbidity (HFrEF and HFpEF): hypertension
2018Hypertensive heart disease is a major cause of heart failure (HF) and mortality. Hypertension precedes HF occurrence in 75% of cases, and carries a sixfold increase in HF risk as compared to non-hypertensive individuals. Most importantly, a minority of patients survive 5 years after the onset of hypertensive HF.
Francesco Paneni, Massimo Volpe
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Comparison Chart: Some Drugs for HFrEF
The Medical Letter on Drugs and TherapeuticsComparison Chart: Some Drugs for ...
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HFrEF pharmacological treatment: beta blockers
2018By incremental steps over several decades of research, beta blockers have evolved ‘from bench to bedside’, emerging as a keystone of modern optimal pharmacotherapy for heart failure. This chapter starts by detailing the story of their development, focusing on the randomized trials that established their clinical efficacy in reducing hospitalization and
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