Results 51 to 60 of about 145 (101)

Determining the Molecular Background of Endometrial Receptivity in Adenomyosis

Biomolecules, 2020
Background: Adenomyosis is a gynaecological condition with limited evidence of negative impact to endometrial receptivity. It is commonly associated with endometriosis, which has been shown to alter endometrial expression patterns.
Erika Prašnikar, Tanja Kunej, Katja Repnik, Uroš Potočnik, Jure Knez, Borut Kovačič   +5 more
doaj   +1 more source

Epigenetic‐Based Evidence for Distinct Effects of Age, Sex, and Experience in Developmental Critical Period Learning

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Although much is known about the encoding of experience, how the brain organizes neural circuits capable of learning and memory formation is largely unstudied. Canonical critical periods emerge from a convergence of maturation‐ and experience‐dependent processes.
Grant W. Kunzelman, Alice Batistuzzo, Sarah E. London   +2 more
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1196-1205, June 2026.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Effect of functionalization of graphene nanoplatelets on the mechanical response of hybrid graphene-fiber reinforced epoxy laminates

Journal of Materials Research and Technology
This study examines the mechanical and fracture behavior of glass fiber-reinforced epoxy laminates enhanced with graphene nanoplatelets (GNPs) to explore the effect of GNP through-thickness distributions on tensile, pin-bearing, and in-plane shear ...
A.M. Sadoun, Amr Seif, Alaa E. Abdelmoniem, Omar E. Elnokity, Waleed Mohammed Abdelfattah, I.M.R. Najjar, M. Megahed   +6 more
doaj   +1 more source

A Novel Gain‐of‐Function ITPR1 Variant Associated With a Movement Disorder Characterized by Tremor and Dystonia

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1261-1266, June 2026.
ABSTRACT The 1,4,5‐trisphosphate receptor type 1 (ITPR1) gene encodes an endoplasmic reticulum calcium release channel, in which loss‐of‐function mutations have been associated with spinocerebellar ataxias and related neurological phenotypes. Only one gain‐of‐function mutation in the highly conserved suppressor domain of ITPR1 has been previously ...
Emilie T. Théberge, Bo Sun, Ruiwu Wang, Arezoo Mohajeri, Clara D. M. Van Karnebeek, Cornelius F. Boerkoel, Stephanie Huynh, Gabriella Horvath, S. R. Wayne Chen, Anna Lehman   +9 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Integrated Molecular Docking and Gene Expression Analyses Suggest a Potential Interaction Between Diphtheria Toxin and Bcl‐2 in HT‐29 Colorectal Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This study explores the interaction between Diphtheria Toxin (DT) and Bcl‐2 in HT‐29 cells. Integrating molecular docking with gene expression analysis, we demonstrate DT's high‐affinity binding to Bcl‐2 and a significant downregulation of BCL2 mRNA. These findings suggest that DT modulates anti‐apoptotic pathways, influencing colorectal cancer cell ...
Elif Ercan, Tugba Yalcinkaya, Belkis Levent, Ahmet Carhan   +3 more
wiley   +1 more source

Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes

Cell Reports, 2012
The ubiquitin-proteasome system is essential for maintaining protein homeostasis. However, proteasome dysregulation in chronic diseases is poorly understood.
Sang Mi Shim, Won Jae Lee, Youngdoo Kim, Jong Wook Chang, Sungmin Song, Yong-Keun Jung   +5 more
doaj   +1 more source

Multi‐Omics Integration Reveals Incomplete Reactivation of Developmental Cell‐Cycle Programs in Adult Human Infarcted Hearts

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Cross‐context integration of single‐nucleus, spatial, bulk transcriptomic, and chromatin accessibility data from human fetal and adult infarcted hearts reveals that infarct‐zone cardiomyocytes re‐enter the cell cycle but show insufficient reactivation of late mitotic and cytokinesis execution programs, suggesting that incomplete cytokinesis ...
Jieran Lyu, Yuki Kuramoto, Jun Li, Jong‐Kook Lee, Kyoko Hidaka, Yasushi Sakata   +5 more
wiley   +1 more source