Results 71 to 80 of about 6,804 (189)

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, Volume 59, Issue 6, June 2026.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1743-1750, June 2026.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

Noise analysis of continuous gravity data in Hailar Earthquake Monitoring Center Station based on HHT

地震科学进展
The continuous observation data of the PET gravimeter at the Hailar Earthquake Monitoring Centre Station from 2021 to 2023 were taken as the research object.
Xinci Zou, Yi Wang, Yuanmeng Tan, Zhihui Jin, Ziqing Ye, Tong Wu, Weipeng Du, Jinling Zhou, Ying Shen   +8 more
doaj   +1 more source

Investigating The Impact Of Homoharringtonine On K562 Cell Viability And ER Stress Pathways [PDF]

BIO Web of Conferences
This study investigated the effects of Homoharringtonine (HHT) on K562 cell proliferation and endoplasmic reticulum (ER) stress. The inhibitory effect of HHT was assessed using the CCK-8 assay to calculate IC50 values. Flow cytometry evaluated cell cycle
Wang Meishi, Zhao Sensen, Yu Shuangle, Zhou Zhaoli   +3 more
doaj   +1 more source

20-year follow-up study of Danish HHT patients—survival and causes of death

Orphanet Journal of Rare Diseases, 2016
Background Hereditary Haemorrhagic Telangiectasia (HHT) is a dominantly inheritable disorder, with a wide variety of clinical manifestations due to presence of multiple arteriovenous manifestations.
Anette Kjeldsen, Katrine Saldern Aagaard, Pernille Mathiesen Tørring, Sören Möller, Anders Green   +4 more
doaj   +1 more source

Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand[S]

Journal of Lipid Research, 2013
12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) has long been considered a by-product of thromboxane A2 (TxA2) biosynthesis with no biological activity.
Takehiko Matsunobu, Toshiaki Okuno, Chieko Yokoyama, Takehiko Yokomizo   +3 more
doaj   +1 more source

Comorbidity among HHT patients and their controls in a 20 years follow-up period

Orphanet Journal of Rare Diseases, 2018
Background Hereditary Haemorrhagic Telangiectasia (HHT) is an autosomal dominant genetic disorder with a wide variety of clinical manifestations due to the presence of multiple arteriovenous malformations in various tissues and organs. Objective To study
Katrine Saldern Aagaard, Anette Drøhse Kjeldsen, Pernille Mathiesen Tørring, Anders Green   +3 more
doaj   +1 more source

Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish

Disease Models & Mechanisms, 2023
Etienne Lelièvre, Charlotte Bureau, Yann Bordat, Maxence Frétaud, Christelle Langevin, Chris Jopling, Karima Kissa   +6 more
doaj   +1 more source

Mutations in the ENG, ACVRL1, and SMAD4 genes and clinical manifestations of hereditary haemorrhagic telangiectasia: experience from the Center for Osler’s Disease, Uppsala University Hospital

Upsala Journal of Medical Sciences, 2018
Aim: The aim of this retrospective single-centre study was to evaluate whether mutations in the ENG, ACVRL1, and SMAD4 genes were associated with different phenotypes in hereditary haemorrhagic telangiectasia (HHT).
Torbjörn Karlsson, Honar Cherif
doaj   +1 more source

Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway

iScience
Summary: Homoharringtonine (HHT), an alkaloid isolated from Cephalotaxus, is an effective anti-leukemia agent and exhibits inhibitory effects in various solid tumors. However, the impacts of HHT treatment on thyroid cancer (TC) remain unclear.
Chuang Xi, Guoqiang Zhang, Nan Sun, Mengyue Liu, Nianting Ju, Chentian Shen, Hongjun Song, Quanyong Luo, Zhongling Qiu   +8 more
doaj   +1 more source