Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia [PDF]
Communications BiologyIncreased levels of soluble endoglin (sEng) are found in serum, plasma, and urine of preeclampsia patients. sEng is released from membrane-bound endoglin through the proteolytic activity of metalloproteases, but its structural heterogeneity suggests the ...
Divina El Hamaoui +14 more
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Endoglin and squamous cell carcinomas [PDF]
Frontiers in Medicine, 2023 Despite the fact that the role of endoglin on endothelial cells has been extensively described, its expression and biological role on (epithelial) cancer cells is still debatable.
Sarah K. Hakuno +12 more
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MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin. [PDF]
PLoS ONE, 2012 Preeclampsia is a major pregnancy complication, characterized by severe endothelial dysfunction, hypertension and maternal end-organ damage. Soluble endoglin is an anti-angiogenic protein released from placenta and thought to play a central role in ...
Tu'uhevaha J Kaitu'u-Lino +4 more
doaj +7 more sources
The Role of the TGF-β Coreceptor Endoglin in Cancer [PDF]
Scientific World Journal, The, 2010 Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and modulates TGF-β signaling.
Eduardo Pérez-Gómez +2 more
exaly +3 more sources
Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway [PDF]
Frontiers in Molecular NeuroscienceIntroductionCentral neuroinflammation is pivotal in neuropathic pain pathogenesis, with blood-spinal cord barrier (BSCB) dysfunction recognized as a trigger for neuroinflammation and pain, though molecular mechanisms remain poorly understood ...
SiJing Liao +14 more
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Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study [PDF]
Dermatology Practical & ConceptualIntroduction: Rosacea, a chronic skin disease characterized by facial redness, is believed to involve inflammation and angiogenesis in its pathogenesis.
Melodi Çekiç +3 more
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EVALUATION OF MATERNAL SERUM ENDOGLIN IN PREECLAMPSIA AND IN NORMOTENSIVE PREGNANT FEMALES [PDF]
Ain Shams Medical Journal, 2022 Background: Preeclampsia is characterized by an imbalance in angiogenic factor, including soluble endoglin. Serum soluble endoglin levels were significantly different in patient with preeclampsia than in healthy pregnancy.Aim of the work: Evaluation of ...
Salma Nassar +4 more
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Sensors and Actuators Reports, 2022 Cell-based Surface Plasmon Resonance imaging (SPRi) with anti-endoglin VHH antibodies microarray on a gold-covered biochip was used to characterize the binding to endoglin expressed on the surface membrane of SC cells. SPRi showed the specific capture of
Milagros Quintana +2 more
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Investigation of endoglin wild-type and missense mutant protein heterodimerisation using fluorescence microscopy based IF, BiFC and FRET analyses. [PDF]
PLoS ONE, 2014 The homodimeric transmembrane receptor endoglin (CD105) plays an important role in angiogenesis. This is highlighted by mutations in its gene, causing the vascular disorder HHT1.
Tassilo Förg +2 more
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Combined perioperative plasma endoglin and VEGF--a assessment in colorectal cancer patients.
Folia Histochemica et Cytobiologica, 2009 Colorectal cancer growth and spread is absolutely dependent on angiogenesis with vascular endothelial growth factor (VEGF) being the most important cytokine involved in the process. Endoglin, a membrane co-receptor for TGF-beta, has recently emerged as a
Krystyna Pawlak +3 more
doaj +3 more sources