Results 21 to 30 of about 13,041 (209)
Endoglin moves and shapes endothelial cells
Nature Cell Biology, 2017 Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGFβ/BMP co-receptor endoglin ...
Bautch, V.L., Victoria L. Bautch
core +3 more sources
Expression of Endoglin in Primary Endometrial Cancer
Oncology, 2011 <i>Objective:</i> Alterations in the transforming growth factor-β (TGF-β) signaling cascade are engaged in the development of human neoplasms through the deregulation of proliferation, differentiation and migration.
Andrzej Semczuk +6 more
core +3 more sources
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Endoglin in head and neck neoplasms
Frontiers in Medicine, 2023 Tumors of the head and neck region form a heterogeneous group of pathologies, including various benign lesions and malignant neoplasms. Endoglin, also known as CD105, is an accessory receptor for transforming growth factor beta (TGF-β), that regulates angiogenesis, both under physiological and pathological conditions.
Małgorzata Litwiniuk-Kosmala +2 more
openaire +3 more sources
Endoglin in liver fibrosis [PDF]
Journal of Cell Communication and Signaling, 2011 Liver fibrosis occurs in most types of chronic liver diseases and is characterized by excessive accumulation of extracellular matrix proteins, leading to disruption of tissue function and eventually organ failure. Transforming growth factor (TGF)-β represents an important pro-fibrogenic factor and aberrant TGF-β action has been implicated in many ...
Kenneth W, Finnson, Anie, Philip
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CD105 (Endoglin), Apoptosis, and Stroke [PDF]
Stroke, 2004 To the Editor: The recent paper by Zhu et al1 in this journal provides an insight into the possible mechanism of hypoxia-induced upregulation of CD105 (endoglin). The following 3 points are relevant to their paper. Lately there has been a major debate regarding the relevance of cell culture/animal models for human stroke in general and for ...
Guo, Baoqiang +4 more
openaire +3 more sources
MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart. [PDF]
PLoS ONE, 2014 MicroRNA-208a (mir-208a) is essential for cardiac hypertrophy and fibrosis. Endoglin, a co-receptor of transforming growth factor-β is also essential for cardiac fibrosis.
Bao-Wei Wang +3 more
doaj +1 more source
BMC Biology, 2022 Background Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin.
Paul-Lennard Mendez +9 more
doaj +1 more source
Negative correlation between endoglin levels and coronary atherosclerosis
Lipids in Health and Disease, 2021 Background Coronary artery disease (CAD) is a common cardiovascular disease, and abnormal blood lipid metabolism is an important risk factor. Transforming growth factor-ß (TGF-ß) and its receptor (TGF-ßR) can inhibit the release of inflammatory factors ...
Haibin Chen +7 more
doaj +1 more source